Key Responsibilities

• Providing technical leadership in hands‑on process development, applying advanced engineering principles to drive the design, build‑out, and maturation of the ECO Synthesis® platform in close partnership with cross‑functional development teams

• Leading the scale‑up strategy for the ECO Synthesis® platform, ensuring process is robust, well‑characterized, and ready for transition into a cGMP manufacturing environment.

• Championing laboratory safety, maintaining a clean and compliant workspace, conducting process hazard analyses and risk assessments, and ensuring safe working environment for all team members.

• Overseeing documentation quality, ensuring batch records, SOPs, and development reports meet GDP standards; providing mentorship and guidance to early‑career engineers and scientists on documentation and experimental/statistical rigor.

• Leading the development and delivery of key technical work, including internal and external presentations, detailed technical reports, and comprehensive technology transfer packages for siRNA manufacturing processes.

• Owning the creation of engineering design tools, including mass and energy balances, process flow diagrams (PFDs), equipment specifications, and cost models to support scale‑up, facility integration, and long‑term platform deployment.

• Serving as primary technical liaison with external vendors, driving equipment selection, qualification, and support activities essential for effective process development and scale‑up.

Skills, Knowledge & Expertise

• Bachelor’s degree in Chemical Engineering, Biochemical Engineering, or related field with 10+ years of relevant industrial experience, or M.S. with 8+ years.
• Expertise in flow chemistry, biocatalysis, or oligonucleotide synthesis technologies (e.g., SPOS, enzymatic platforms).
• Demonstrated leadership in scale‑up activities, including tech transfer of biocatalytic or nucleic acid–based processes from laboratory to pilot or commercial manufacturing environments.
• Proficiency in process modeling and simulation tools such as Aspen Plus, SuperPro Designer, COMSOL, or DynoChem; and proficient with data analytics or scripting tools (e.g., R, JMP, Python).
• Strong leadership, communication skills, with the ability to collaborate effectively across cross-functional teams including R&D, Operations, Quality, and Engineering.

Additional experience that would be valuable for this role includes:

• Prior experience managing early career engineers, scientist, or research associates.

• Expertise in purification technologies, such as chromatography, filtration, or enzyme/oligonucleotide purification workflows.

• Experience with facility design or equipment specification, for nucleic acid manufacturing.

• Deep understanding of quality systems and regulatory expectations, including ISO-based quality frameworks and GMP principles.

Job Benefits

• Medical, Dental and Vision Insurance 

• Basic Life, AD&D, Short- and Long-Term Disability Insurance 

• 401k with Company Match up to 4% 

• Company Equity 

• Generous Paid Time Off including 18 Company Holidays (with a summer and winter shutdown), Vacation, and Wellness Time 

• Annual Lifestyle Account for reimbursement of fitness programs, equipment and more 

• Employee Stock Purchase Program (ESPP) 

• Flexible Spending Accounts (Commuter/Parking, Dependent Care & Healthcare)

• Student Debt Program (Company Contribution to Loans)

• Mental Health Wellness Program

• Subsidized onsite lunch program

• Onsite Gym Facilities

• Paid Parental Leave

And More!