Scientist - Preclinical Development, Translational Biology
- Employer
- Terray Therapeutics
- Location
- Monrovia, CA
- Start date
- Jan 29, 2025
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- Discipline
- Science/R&D, Biology, Biotechnology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Biotech Beach, Best Places to Work
Job Details
- Cell-based assay mechanistic studies
- Review the literature to gain a comprehensive understanding of therapeutic targets of interest
- Develop and optimize cell-based assays to support lead candidate selection and/or broader understanding of the therapeutic potential of small molecule inhibitors
- Design and execute studies to elucidate the mechanism of action of novel small molecule inhibitors
- Disease-relevant mechanistic studies
- Design and establish disease relevant assays to provide supporting data for different therapeutic indications and/or rodent models of diseases
- Support in vivo pharmacology efforts with ex vivo studies associated with PK-PD or disease models
- Biomarker assay development
- Identify and develop biomarker assays for early clinical trials
- Facilitate the transfer of biomarker assays to CRO for phase 1 studies
- Data analysis and collaboration
- Analyze and interpret experimental data, and communicate results in our project team meetings
- Collaborate across multidisciplinary teams including chemistry, platform, screening and data teams to efficiently move projects forward
- Lab support
- Assist in evaluating and setting up new lab instrumentation
- Contribute to the organization and maintenance of lab equipment as needed
- PhD with 5+ years of academic/industry research experience in immunology, immuno-oncology, or a related field
- In-depth knowledge of autoimmune and inflammatory disease models is highly desirable
- Background in small molecule drug discovery strongly preferred
- Proficiency in standard immunological assays (primary cell isolation and culture, flow cytometry, cytokine detection and gene expression analysis)
- Extensive hands-on experience with western-blotting, immunoprecipitation and similar protein sciences techniques
- Experience with screening small molecules in medium through-put cell-based assays and small molecule mechanism of action studies ideas
- Experience with molecular biology techniques and cell line construction
- Excellent organizational, interpersonal and communication skills and can thrive in a highly collaborative research environment
- Demonstrated technical proficiency, ability to troubleshoot to solve problems and to deliver high quality data
Company
Terray is a biotechnology company with the technology, data, and mindset to radically change the way we discover and develop small molecule therapeutics. We explore molecules and targets broadly and deeply with a sophisticated integration of ultra-high throughput experimentation, generative AI, biology, medicinal chemistry, automation, and nanotechnology. Everything the company does is grounded in an iterative approach, producing massive amounts of precise, purpose-built data that gets increasingly valuable with each cycle of design and experimentation. The company’s platform uniquely blends experimentation and computation to improve the cost, speed, and success rate of small molecule drug discovery and development.
- Website
- http://www.terraytx.com/
- Location
-
750 Royal Oaks, Suite 100
Monrovia
CA
91016
US
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