Director, Data Science, R&D
- Employer
- Avidity Biosciences
- Location
- San Diego, California
- Start date
- Jan 24, 2025
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- Discipline
- Information Technology, Business/Data Analytics, Regulatory
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Biotech Beach
Job Details
- Develop, fine-tune, and apply nucleotide-focused AI models (e.g., DNABERT, Transformer-based architectures) for genomic and transcriptomic analyses.
- Analyze gene expression datasets to optimize RNA-based therapeutic designs and identify key biological patterns.
- Build machine learning models for RNA therapeutics, including applications in sequence specificity, off-target prediction, and functional validation.
- Work with multi-omics data (e.g., RNAseq, proteomics) to integrate insights into model development and therapeutic strategy.
- Collaborate with research, technical development, and clinical teams to translate AI-driven insights into actionable results.
- Lead the development of computational tools and pipelines for nucleotide data analysis.
- Stay at the forefront of AI and genomic data science, exploring novel methodologies to improve the design and delivery of RNA-based therapies.
- Partner with stakeholders to develop and drive the computational research strategy to accelerate our drug discovery process
- PhD in Computational Biology, Bioinformatics, Genomics, Machine Learning, or a related field, or equivalent industry experience. Background and experience in the life sciences is key.
- Strong expertise in nucleotide modeling and related machine learning approaches (e.g., DNABERT, nucleotide Transformers) with 10+ years of experience.
- Proficiency in Python and machine learning frameworks such as TensorFlow or PyTorch.
- Experience analyzing siRNA data, with a solid understanding of RNA interference and oligonucleotide design.
- Hands-on experience with multi-omics data (RNAseq, proteomics, etc.) and bioinformatics tools.
- Familiarity with genomic databases and annotation tools (e.g., ENSEMBL, UCSC Genome Browser).
- Strong problem-solving and organizational skills, with the ability to work collaboratively in a cross-functional environment.
- Strong data visualization experience focused on making results easily sharable across multiple scientific and business teams.
- Excellent written and verbal communication skills, with a track record of publishing or presenting technical work.
- The base salary range for this role is $237,500 - $262,500. The final compensation will be commensurate with relevant experience, skillset, internal equity, and market factors.
- Avidity offers competitive compensation and benefits, including the opportunity for annual and spot bonuses, stock options, and RSUs, as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, and LTD and four weeks of time off.
- A commitment to learning and development, including a variety of internal programming developed by and for Avidity employees, opportunities for job-specific training offered by industry, and an education reimbursement program.
#LI-DNI
Company
Our vision is to profoundly improve people’s lives by revolutionizing the delivery of RNA therapeutics. We’re utilizing our proprietary AOC platform to design, engineer, and develop therapeutics that combine the tissue selectivity of monoclonal antibodies (mAbs) with the precision of oligonucleotide-based therapies in order to redefine RNA therapeutics and more effectively target underlying genetic drivers of diseases. We are delivering on this vision by investing in our platform, our pipeline and our people.
Our commitment to rigorous and innovative science is matched only by our passion to see patients’ lives changed. We consistently challenge ourselves to Be AVID – Agile, Visionary, Integrated and Diverse.
We are assembling a diverse team experienced in rare disease and RNA therapies. Our team members bring expertise in research, development and commercial execution. We are focused on cultivating the right team to not only grow the company, but also to reflect the communities we serve. We are dedicated to employing and retaining a diverse and inclusive workforce at all levels of the organization to not only ensure that different backgrounds and perspectives are being heard and acted upon, but that our employees also feel understood, accepted and valued.
- Website
- http://www.aviditybiosciences.com/
- Phone
- 858-401-7900
- Location
-
10578 Science Center Drive
Suite 125
San Diego
California
92121
US
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