Bioinformatics Scientist - Proteomics - Drug Discovery Technologies
- Employer
- Nurix Therapeutics
- Location
- San Francisco, CA
- Start date
- Jan 24, 2025
View more categoriesView less categories
- Discipline
- Information Technology, Bioinformatics, Science/R&D, Biotechnology, Pharmacology
- Required Education
- Masters Degree/MBA
- Position Type
- Full time
- Hotbed
- Biotech Bay
Job Details
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Position
Nurix is seeking a candidate for the role of Bioinformatics Scientist in the Proteomics group within Discovery Technologies and Early Research. This individual contributor role will focus on designing, implementing, and optimizing tools and workflows for proteomics data analysis, visualization, and interpretation. The candidate will creatively expand the capabilities of Nurix’s proteomics platform by integrating and developing customized tools for both global and targeted proteomics data analysis workflows. In this highly collaborative position, the candidate will work closely with proteomics team members, IT & informatics teams, biologists, and project leads, applying their tools and expertise to advance targeted protein degradation drug discovery. This candidate will also implement tools used throughout the degrader R&D life cycle to advance drug candidates alongside colleagues in Medicinal Chemistry, Biology, and Safety Assessment.
Required Skills & Experience:
Ph.D. in Biology, Chemistry, Biochemistry, Bioinformatics, or a related field with 0-3 years post-Ph.D. experience
- Expertise in:
- Bioinformatics analysis of proteomic datasets with a focus on global proteomics workflows; familiarity with targeted proteomics is also valuable
- Tools used for analyzing and visualizing differential expression datasets
- Development and optimization of scripts in R and/or Python for proteomics data analysis
- Standard statistical methods for large-scale data interpretation
- Strong experience in analyzing, condensing, and presenting complex datasets to diverse teams
- Knowledgeable in computational applications for global proteomic data
- Knowledgeable in post-translational modification (PTM) enrichment workflows
Preferred Skills & Experience
- Experience implementing or managing proteomics-related databases
- Direct experience with MS data processing tools & software
(eg Skyline, Spectronaut/DIA-NN, MaxQuant, FragPipe) - Knowledge of protein ubiquitylation biochemistry and pathways
- Familiarity with cloud computing platforms (e.g., AWS) for data storage and analysis
- Experience with machine learning (ML) or artificial intelligence (AI) for data analysis
- Knowledge of protein degradation pathways or prior experience in degrader drug discovery
- Strong publication record (e.g., peer-reviewed publications) and conference presentations.
Culture & Team Fit:
- Ability to work collaboratively across multiple groups within the organization
- Excellent organization and communication with effective presentation skills
- Self-driven and enthusiastic with proficiencies to deliver in a dynamic environment
- Curious mindset with a willingness and flexibility to learn new skills
- High level of creativity and productivity with strong problem-solving skills
Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix. By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy (https://www.nurixtx.com/privacy-policy/).
Company
Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.
Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.
- Website
- https://www.nurixtx.com/
- Phone
- 415-660-5320
- Location
-
1700 Owens Street
Suite 205
San Francisco
California
94158
United States
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