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Associate Scientist/Scientist Biologic Conjugates Purification

Employer
JLSa2 Therapeutics, Inc
Location
94080, South San Francisco
Salary
$100,000 - $130,000 + benefits (Subject to experience, could fall outside range)
Start date
Jan 17, 2025
View more categoriesView less categories
Discipline
Science/R&D, Biotherapeutics, Chemistry, Laboratory
Required Education
Bachelors Degree
Position Type
Full time

JLSa2 is a new and recently launched seed-stage venture backed company, located in South San Francisco, focused upon developing novel multifunctional protein-drug conjugate therapies to address human metabolic diseases and other non-oncology related diseases. 

The company is seeking an Associate Scientist/Scientist to develop purification schemes and lead scale up efforts for production of biologic conjugates as well as support analytical characterization of our protein conjugates for progression of lead molecules from research stage through early clinical development. 

Responsibilities:

The candidate will lead purification efforts of biologic conjugates ranging in scale from milligram to gram quantities.  The candidate will perform phase appropriate formulation studies to address potential solubility, aggregation, recovery challenges.  The candidate will work in a highly collaborative team with the analytical and biologic assays teams, as well as senior leadership, to ensure data integration across functional areas to ensure rapid decision making and product iteration cycle time.  This position is expected to be on site at our SSF facility.

 

Qualifications:

BS/MS in biochemistry, biophysics, analytical chemistry or related scientific field and minimum- 4-6 years of industry experience in purification and characterization of biologic molecules is required.

Proficient in using AKTA Pure and AKTA Pilot systems is required, preferable to have experience in purifying antibody and antibody drug conjugates, experience in typical analytical characterization assays such as RP-HPLC, SEC, CEX, HIC, and SDS-PAGE is a plus. 

Demonstrated problem solving experience and management of purification work and is expected to be hands on in the lab, experience reviewing, organizing, and presenting analytical data is preferred.

Knowledge of formulation study design and analysis, DoE experience is a plus. 

Flexibility to work on multiple projects in a fast-paced start up environment is essential.

Good communication skills are essential.  

Salary Range: $100,000 - $130,000 (Compensation and level will be commensurate with experience and expertise and could fall outside of the stated range)

 

Competitive benefits package is offered that includes health, dental, and vision insurance, life insurance, 401K plan, non-accruing PTO, and early-stage equity.

 

JLSa2 is a new and recently launched seed-stage venture backed company, located in South San Francisco, focused upon developing novel multifunctional protein-drug conjugate therapies to address human metabolic diseases and other non-oncology related diseases. 

 

The company is seeking an Associate Scientist/Scientist to develop purification schemes and lead scale up efforts for production of biologic conjugates as well as support analytical characterization of our protein conjugates for progression of lead molecules from research stage through early clinical development. 

 

 

 

Responsibilities:

 

The candidate will lead purification efforts of biologic conjugates ranging in scale from milligram to gram quantities.  The candidate will perform phase appropriate formulation studies to address potential solubility, aggregation, recovery challenges.  The candidate will work in a highly collaborative team with the analytical and biologic assays teams, as well as senior leadership, to ensure data integration across functional areas to ensure rapid decision making and product iteration cycle time.  This position is expected to be on site at our SSF facility.

 

Qualifications:

 

BS/MS in biochemistry, biophysics, analytical chemistry or related scientific field and minimum- 4-6 years of industry experience in purification and characterization of biologic molecules is required. Proficient in using AKTA Pure and AKTA Pilot systems is required, preferable to have experience in purifying antibody and antibody drug conjugates, experience in typical analytical characterization assays such as RP-HPLC, SEC, CEX, HIC, and SDS-PAGE is a plus.  Demonstrated problem solving experience and management of purification work and is expected to be hands on in the lab, experience reviewing, organizing, and presenting analytical data is preferred. Knowledge of formulation study design and analysis, DoE experience is a plus.  Flexibility to work on multiple projects in a fast-paced start up environment is essential. Good communication skills are essential.  

 

Salary Range: $100,000 - $130,000 (Compensation and level will be commensurate with experience and expertise and could fall outside of the stated range)

 

Competitive benefits package is offered that includes health, dental, and vision insurance, life insurance, 401K plan, non-accruing PTO, and early-stage equity.

 

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