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Senior Scientist II - Process Chemistry

Employer
Novo Nordisk
Location
Boulder, CO
Start date
Dec 10, 2024
View more categoriesView less categories
Discipline
Engineering, Science/R&D, Biotechnology, Chemistry
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Genetown, Best Places to Work

Job Details

About the Department   

The Boulder Site is home to the specialized technical operations/CMC team for oligonucleotides and RNAi therapeutics, continuing its legacy as the hub for all manufacturing-related activities for GalXC™ and GalXC-Plus™ investigational therapeutics developed from Novo Nordisk’s acquisition of Dicerna Pharmaceuticals, Inc. in December 2021. With a new laboratory completed in 2021 to support analytical and process development, the CMC team works alongside Quality, Regulatory, Technical Operations and RNAi Early Development professionals at our Boulder, Colorado facility and works closely with our teams in Lexington, Massachusetts. Ranked the No. 1 Place to Live for the second consecutive year by U.S. News & World Report, Boulder is experiencing a renaissance in biotech investment and is one of the world’s leading centers for oligonucleotide innovation and manufacturing. Together, we are driving change. Are you ready to make a difference?

 

The Position

Novo Nordisk is seeking a Senior Scientist to join our RNAi Chemical Development group in Boulder, Colorado. You will lead and drive process development for the enzymatic ligation of oligonucleotides, biocatalytic processes pertaining to RNA synthesis, bioconjugation, and trans glycosylation of nucleosides. The successful candidate will be a scientific contributor in the development of enzymatic processes used to manufacture raw materials and API candidates in our portfolio.

 

Relationships

Reports to Senior Director, Chemical Development.

 

Essential Functions

  • Lead the development, optimization, and scale up of biocatalytic and traditional synthetic production of small molecules, oligonucleotide intermediates and API’s at kilogram scale, utilizing principles of process chemistry and chemical engineering
  • Provide leadership for the setup and commissioning of kilo lab facility, ensuring compliance with all relevant safety, regulatory, and quality standards
  • Work closely with cross-functional teams, including research and development, analytical chemistry, and manufacturing, to transfer processes from the kilo lab to pilot plant and production scale
  • Manage and mentor junior chemists and technicians, providing technical guidance, training, and support to ensure efficient and high-quality operations
  • Support regulatory filings as necessary
  • Implement and enforce robust safety protocols and procedures within the kilo lab, ensuring adherence to all relevant regulations and standards
  •  

    Physical Requirements

    0-10% occasional overnight travel (domestic or international) to support technology development and technology transfer to commercial manufacturing. Ability to lift 0 – 20lbs.

     

    Development of People

    Supervisory

    Ensure that reporting personnel have individual development plans (IDP), with annual goals and measurements that are consistent with the priorities of the business, and that interim reviews are held so that their work is focused on those priorities, and they understand their level of accountability for results and the measurement process.

     

    Ensure that the IDP forms include completed learning and aspiration plans and are in place for all reporting personnel to enable the achievement of goals and capability to assume increased levels of responsibility.

     

    Manage the application and communication of all Novo Nordisk policies, procedures, and Novo Nordisk Way.

     

    Qualifications

  • PhD in Chemistry, Biochemistry or related field with 6 years, MS with 10 years, or BS with 12 years of relevant industrial or post-doctorate experience required, preferably in an FDA regulated environment
  • In-depth knowledge of small molecule process chemistry and standard analytical methods, experience with biocatalytic reactions preferred
  • Outstanding aptitude for experimental design and execution, efficient assay development, and creative problem solving
  • Familiar with GMP and regulatory requirements around the drug development process
  • Strong communication and collaboration skills, along with multiple examples of a strong technical background
  • Ability to function in a timeline-driven, dynamic environment, and rapidly adapt to new techniques and protocols
  • A strong work ethic and high level of motivation
  •  

     

    "The base compensation range for this position is $160,000 to $ 170,000. Base compensation is determined based on a number of factors. This position is also eligible for a company bonus based on individual and company performance.  The job posting is anticipated to close on 12/16/2024. The Company may however extend this time-period, in which case the posting will remain available on our careers website at www.novonordisk-us/careers.com.

     

    Novo Nordisk offers long-term incentive compensation and or company vehicles depending on the position's level or other company factors. 

     

    Employees are also eligible to participate in Company employee benefit programs including medical, dental and vision coverage; life insurance; disability insurance; 401(k) savings plan; flexible spending accounts; employee assistance program; tuition reimbursement program; and voluntary benefits such as group legal, critical illness, identity theft protection, pet insurance and auto/home insurance. The Company also offers time off pursuant to its sick time policy, flex-able vacation policy, and parental leave policy."

     

    We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.

     

    At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.

     

    Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.

     

    If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1-855-411-5290. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.

    Company

    Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat diabetes and other serious chronic diseases such as obesity and rare blood and endocrine disorders. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure disease. Novo Nordisk employs about 54,400 people in 80 countries and markets its products in around 170 countries. For more information visit novonordisk.com.

    Our US Research & Development hub, located in the Greater Boston area, brings together the best talent to drive life science innovation. Located in Lexington, Watertown and Cambridge, our teams reflect the full scope of R&D, from early research through late-stage clinical development. We are building for the future by creating a distinct R&D community based on collaboration, partnerships, and cutting-edge research across multiple modalities and therapeutic areas. We recognize that improving human health starts here and that patients rely on us. By combining the speed and agility of biotech with the quality, resources, and stability of a large pharmaceutical company, our US R&D hub will benefit from the best of both worlds to develop new medicines that meet the needs of patients.

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    Company info
    Website
    Phone
    617-612-6200
    Location
    75 Hayden Avenue
    Lexington
    MA
    02421
    United States

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