Senior Scientific Lead - Translational Sciences

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

Organization Overview:
Lilly oncology conducts discovery research, clinical development, and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. The Senior Scientific Lead will be part of the Translational Sciences group in Indianapolis, IN. The Translational Sciences group is responsible for developing and executing strategies for precision medicine including identifying and validating biomarkers, establishing combination strategies and understanding drug resistance. The Senior Scientific Lead will have a strong understanding of cell cycle and signal transduction pathways. This is a hands-on position for an experienced scientist who enjoys working in the lab. The successful candidate must have excellent people skills and be able to work with a positive, “can-do” attitude in a dynamic, fast-paced, team environment focused on high quality science to deliver innovative cancer drugs. 

Responsibilities:

• Design and execute key experiments to evaluate compounds, identify combination partners and investigate drug resistance.
• Design and manage in vivo studies
• Translate preclinical findings to biomarker and combination strategies to advance programs to clinical development
• Work closely with clinical team to develop and test hypotheses that could determine the clinical response and define the patient populations. 
• Engage in cross-functional collaborations across the company.
• Identify, evaluate, and manage vendors for outsourced services and studies.
• Prepare reports for internal and external purposes including regulatory submissions.
• Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies.

Basic Requirements:

• PhD in Molecular/Cellular Biology or Biochemistry, or related field and 6+ years hands-on molecular and cell biology experience
• OR a BS/MS in Molecular/Cellular Biology or Biochemistry and 10+ years hands-on molecular and cell biology experience

Additional preferences:

• Work experience in a biotech/pharma setting preferred
• Extensive experience in developing and running cellular assays; engineering cell lines to express or knock-down/knock-out genes of interest.
• Experience with general molecular biological techniques including q-PCR, ELISA, assays for protein-protein interactions and Western Blot etc.
• Experience in experimental curve-fitting and statistics helpful.
• Experience in building up models (cell line, organoid or PDX) from patient samples and using them to test drug activities.
• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.
• Highly organized with excellent analytical, documentation and multi-tasking skills.
• Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.
• Enthusiastic, self-motivated and keen to improve processes and overcome inefficiencies.

Additional Information:

The physical demands of this job are consistent with working in a laboratory/ bench environment. Some light lifting, and maneuvering may be required.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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