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Principal Scientist - Mathematical Modeling of Microphysiological Systems

Employer
Novo Nordisk
Location
Watertown, MA
Start date
Nov 8, 2024
View more categoriesView less categories
Discipline
Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Genetown, Best Places to Work

Job Details

About the Department                                                                                             

Our global department is anchored within Global Drug Discovery (GDD) in Research & Early Development (R&ED) with scientists based both in Måløv and Boston, supporting our portfolio with pharmacokinetic (PK) and pharmacodynamic (PD) evaluations using a variety of modelling and simulation tools. Mechanistic modelling (QSP) is an important part of our capabilities. The models we develop and apply help to understand resistance mechanisms, support drug discovery, optimize dose & schedule selection and combination therapy and much more. 

The Position

In this role, you will combine your expertise in modelling and simulation with cutting edge pharmacology (both clinical and pre-clinical) and bioengineering and provide scientific leadership in advancing novel therapies to the clinic with minimal non-clinical in vivo studies. Indeed, you will be part of a growing team that collectively drives the implementation of humanized pre-clinical research (MPS) and connects the insights and output to biobanks/clinical trial data, and vice versa. This requires efficient collaboration and communication with other subject matter experts. Mathematical modelling is crucial to bridge the translational gap, e.g. by tailormade modeling of the MPS system and the relevant human physiology, and will inform and support drug discovery, development and regulatory interactions.

 

Relationships

You will be reporting to the Head of Discovery PKPD and QSP modelling, a recently established department to support the therapeutic areas of NN. You will work closely with highly skilled and dedicated colleagues supporting projects from early discovery, through non-clinical development, as well as early clinical development. In our daily work, we have close collaboration with all parts of the global Discovery and Development organization, research project teams as well as external collaborators.  Key stakeholders include experimental scientists, project managers and, through presentation of your work at decision meetings, senior managers (VP+ level).

 

Essential Functions

Identification of the current knowledge gaps and outstanding questions and converting the relevant biology, biophysical MPS setups, and question(s) into mathematical formulation that can be addressed with modeling and simulation. Being an innovator within QSP and driver of collaborations with MPS bioengineers, scientists, and clinicians to solve unique and complex problems, enabling closure of translational gaps. Anticipating internal and/or external business challenges and issues; recommending process, product or service improvements.Regularly leading project teams to achieve milestones and objectives.Contributing to the development of functional strategies to foster innovation within and to the NN pipeline.We value diversity! So, no matter whether you have modelled climate/weather, ecology, biological networks or other natural processes we would like to hear from you! 

 

Qualifications

  • Ph.D. and 10+ years of post-doctoral experience and at least 5 years in an industry setting; Master’s Degree with 16 years of relevant industry experience; or a Bachelor’s Degree with at least 22 years of relevant experience is required.
  • Relevant experience within Engineering, Physics, Math, or other disciplines related to quantitative biology/pharmacology with a strong emphasis on modelling and simulation of natural processes using mechanistic and/or a combination of mechanistic & empirical models.
  • Excellent understanding of theory, principles, and statistical aspects of advanced mathematical modelling and simulation within physiology and pharmacology, e.g., hands-on experience with system biology, pharmacokinetics, or Physiologically Based Pharmacokinetics. Your ability to translate these tools into actionable insights is exceptional.
  • Demonstrated expertise with ODEs, PDEs, ABMs, optimization, empirical approaches (statistics, ML) and ability to maintain state of the art know-how within QSP.
  • Programming skills with modelling or analytical software (e.g., Matlab/SimBiology, Python, Julia, and/or R).  
  • Perceived as expert within the metabolic syndrome and/or liver-related diseases.
  • Demonstrated strong ability to work in interdisciplinary teams, preferably with a focus to support and integrate in vitro and clinical pharmacology data into QSP models that describe the dynamic interactions between drug(s) and biological systems.
  • Ability to operate with no or little supervision in a complex environment and disseminate knowledge by mentoring colleagues and/or supervising students.
  • Demonstrated successful ability to engage, manage, and collaborate with external partners or service providers
  • Previous experience with MPS and/or similar experimental setups is an advantage
  • Keen to learn new skills and able to communicate with experts of other areas, effectively interact with colleagues with a variety of backgrounds, and have excellent written and oral communication skills in English. 

 

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.

 

At Novo Nordisk we recognize that it is no longer good enough to aspire to be the best company in the world. We need to aspire to be the best company for the world and we know that this is only possible with talented employees with diverse perspectives, backgrounds and cultures. We are therefore committed to creating an inclusive culture that celebrates the diversity of our employees, the patients we serve and communities we operate in. Together, we’re life changing.

 

Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.

 

If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply, please call us at 1-855-411-5290. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.

Company

Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat diabetes and other serious chronic diseases such as obesity and rare blood and endocrine disorders. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure disease. Novo Nordisk employs about 54,400 people in 80 countries and markets its products in around 170 countries. For more information visit novonordisk.com.

Our US Research & Development hub, located in the Greater Boston area, brings together the best talent to drive life science innovation. Located in Lexington, Watertown and Cambridge, our teams reflect the full scope of R&D, from early research through late-stage clinical development. We are building for the future by creating a distinct R&D community based on collaboration, partnerships, and cutting-edge research across multiple modalities and therapeutic areas. We recognize that improving human health starts here and that patients rely on us. By combining the speed and agility of biotech with the quality, resources, and stability of a large pharmaceutical company, our US R&D hub will benefit from the best of both worlds to develop new medicines that meet the needs of patients.

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Company info
Website
Phone
617-612-6200
Location
75 Hayden Avenue
Lexington
MA
02421
United States

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