Director, Quantitative Pharmacology
- Employer
- Amgen
- Location
- South San Francisco, California
- Start date
- Nov 7, 2024
View more categoriesView less categories
- Discipline
- Science/R&D, Pharmacology
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Biotech Bay, Best Places to Work
Job Details
HOW MIGHT YOU DEFY IMAGINATION?
If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. Its time for a career you can be proud of.
Director, Quantitative Pharmacology
LiveWhat you will do
Lets do this. Lets change the world. In this vital role you will characterize the absorption, distribution, metabolism, excretion and pharmacokinetic (ADME) properties of therapeutic drug candidates to achieve their full pharmacological potential. In this role, your core responsibilities include leading a team of pre-clinical PKPD, PBPK and QSP modelers responsible for:
Planning and execution of mechanistic PKPD analyses to integrate knowledge of drug design parameters, disease pharmacology, physiology, pharmacokinetics and pharmacodynamics, and to optimize selection doses and preclinical study designs.
Working closely with discovery scientists (biologists, (protein)chemist, biochemist, pharmacologist, toxicologists) to codify their knowledge and discover new insights using advanced PKPD modeling techniques.
Contributing to the analysis of pre-clinical PKPD data for IND and NDA/BLA filings, and documentation in appropriate reports.
Work closely with business development group to evaluate external opportunities
Build close relationships with partner functions and therapeutic areas
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The professional we seek will possess these qualifications.
Basic Qualifications:The ideal candidate will have a strong background in integrating preclinical data sets to aid in the development of translational PK/PD models.
Candidate should have solid technical expertise in quantitative pharmacology and strong hands-on modeling and simulation experience with Pheonix WinNonlin, R, SimBiology, SimCYP, GastroPlus and/or other modeling and simulation software and data visualization tools.
Experience in managing and mentoring junior modelers and scientists
Ability to drive the progression of discovery and development project teams
Lead development of scientific strategy across PKDM initiatives with a focus on development of integrated PK/PD, QSP and PBPK models to aid in translation.
Develop and mentor PKDM staff. Establish modeling workflows for PKDM scientists.
PhD in Pharmacokinetics, Pharmaceutical Sciences, Engineering, or related fields with equivalent professional degrees and 10+ years of experience in the Biotechnology/Pharmaceutical Industry, consulting or post-doctoral training
Expertise in PK/PD and translational modeling
Experience in supporting preclinical/clinical PK, PK/PD, and modeling & simulation components of regulatory documentations.
Excellent interpersonal, technical, and communication skills to lead cross-functional teams
Past experience as a laboratory scientist and in a biotech environment
Excellent written and oral communication skills, attention to detail and accuracy, and interpersonal skills
Record of scientific contributions through peer-reviewed articles and external presentations
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:
Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans and bi-annual company-wide shutdowns
Flexible work models, including remote work arrangements, where possible
for a career that defies imagination
Objects in your future are closer than they appear. Join us.
careers.amgen.comAmgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Company
We are all different, yet we have this in common: our mission to serve patients. This sense of shared purpose is key to our becoming one of the world’s leading biotechnology companies. It guides us as we continue to launch new medicines and reach millions of patients worldwide.
We live the mission.
We win together.
We thrive on continual challenge.
Our team of 22,000+ scientists and professionals worldwide bring distinct perspectives and experiences to all we do. We leverage our global talent to achieve together—to research, manufacture and deliver ever-better products and greater depth to our mission.
At Amgen, there is a strong correlation between our high level of diversity and performance. Because addressing issues with a wider range of perspectives and approaches leads to more creative problem-solving. Together, we’re transforming the promise of science and biotechnology into therapies that have the power to restore health.
Connect with us to explore how you can Win, Live, and Thrive at Amgen.
- Website
- http://careers.amgen.com/
- Phone
- 805-447-1000
- Location
-
Corporate Headquarters
One Amgen Center Drive
Thousand Oaks
California
91320-1799
United States
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