VP, Medical Affairs
- Employer
- 4D Molecular Therapeutics
- Location
- Emeryville, California
- Start date
- Oct 14, 2024
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- Discipline
- Clinical, Medical Affairs
- Required Education
- Doctorate/PHD/MD
- Position Type
- Full time
- Hotbed
- Biotech Bay, Best Places to Work
Job Details
Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.
4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.
Company Differentiators:
• Fully integrated clinical-phase company with internal manufacturing
• Demonstrated ability to move rapidly from idea to IND
• Five candidate products in the clinic and two declared pre-clinical programs
• Robust technology and IP foundation, including our TVE and manufacturing platforms
• Initial product safety and efficacy data substantiates the value of our platforms
• Opportunities to expand to other indications and modalities within genetic medicine
GENERAL SUMMARY
As a key member of the 4DMT team, this person will provide overall leadership for the Medical Affairs function, overseeing Medical Affairs and supporting business development. The position will inform clinical studies and liaise closely with the physicians responsible for carrying out 4DMT’s clinical studies. This person should be a “leader/doer” capable of generating strategies and leading cross functionally. This VP, Medical Affairs will report directly to the Chief Development Officer.
RESPONSIBILITIES:
Lead the Medical Affairs function at 4DMT
- Develop and implement key Medical Affairs strategies and activities to support the development of our lead assets
- Develop and present Medical Affairs operational plans to Development and Executive management
- Represent company externally
- Direct and oversee all aspects of Medical Affairs and pre-launch needs
- As a member of the Development Leadership Team, run and continue to build the Medical Affairs function
- Build and lead a best-in-class global medical affairs team to support launches of 4D-150 and other development candidates multiple indications including, but not limited to, nAMD and diabetic eye disease.
- Develop key performance indicators and generate analytical reports related to Medical Affairs plans and External Liaison group activities
- Develop and implement Medical Communication and Disease State Awareness strategies
- Partner with KOLs to gather information on current focused therapeutic area issues and questions
- Collaborate with the Commercial team to develop educational material for providers and patients that are balanced and medically accurate
- Provide direction and input into the development and implementation of successful reimbursement and market-access strategies
- Work closely with the members of the clinical development and commercial leadership teams to develop the overall strategic direction for 4DMT, evaluate alternative strategies, identify competitive issues, and develop and implement operating plans to achieve company objectives
- Foster collaborative relationships with academic and clinical experts, publishers, medical and patient associations, and other relevant external and internal stakeholders
- Develop and manage departmental budgets that effectively achieve desired goals that are balanced with the financial objectives of the broader organization Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time
QUALIFICATIONS:
Education | Experience | Skill Requirements
- Advance degree (MD, PhD, or PharmD)
- 10+ years of professional experience within Biotech/Pharma in Medical Affairs
- 5+ years of people leadership experience
- An understanding of government and industry guidelines, regulations, laws, etc., for appropriate scientific/medical exchange and communication with customers
- Ability to lead by example, attract and develop talent, build interdependent partnerships, and create a culture of collaboration and teamwork that fosters open communication, constructive conflict resolution and organizational flexibility
- Ability to prioritize and manage several complex projects simultaneously
- Proven ability to develop internal relationships in a highly matrixed environment, as well as external relationships with Key Opinion Leaders and industry experts
- Ability to communicate effectively at all levels and present complex and/or new ideas with clarity and simplicity
- Ability to prioritize concurrent projects with tight deadlines and operate in a highly compliance-driven environment
- Excellent written, verbal, and interpersonal skills, and the ability to communicate at all levels within the company
- Travel (25-40%) may be required to represent the company at medical conferences, presentations, and other meetings
Base salary compensation range: $336,000 - $394,000
Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience.
4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws. Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities
Company
4DMT is a gene therapy company with a transformative discovery platform --Therapeutic Vector Evolution --that enables our “disease first” approach to product discovery and development, thereby allowing us to customize our AAV vectors to target specific tissue types associated with the underlying disease.
At 4DMT we are creating and developing optimized “biopharmaceutical grade” AAV vectors that will allow us uniquely to unlock the full potential of gene therapy. Our customized and proprietary AAV vectors are each designed, according to a 4DMT Target Vector Profile, to deliver genes to specific cells and tissues in the body to eradicate both rare and large market diseases.
While AAV gene therapy pioneers are making great strides with the first wave of products, hurdles still exist with the use of conventional vectors. The most commonly used AAV capsids (e.g., AAV2, 5, 8 and 9) were identified either 1) as contaminants in lab stocks of adenovirus, or 2) through monkey tissue processing. Therefore, these conventional vectors are not targeted specifically to any tissue in the body. This can lead to inefficient and non-specific delivery, thus requiring extremely high doses and potentially resulting in toxicities (including inflammation), high manufacturing burdens and suboptimal efficacy. In addition, suboptimal routes of delivery can be required for delivery to the right tissues (e.g., subretinal delivery to the retina). Finally, pre-existing neutralizing antibodies in many patients can limit efficacy, clinical trial enrollment and market sizes. 4DMT Innovation empowers us to create new and improved next generation AAV capsids to allow targeted delivery of our products by the optimal clinical route of administration.
At 4DMT we use our robust discovery platform, termed “Therapeutic Vector Evolution,” to create customized and proprietary gene delivery vehicles (novel AAV vectors) to deliver genes to specific tissues and cells in the body by the optimal route of administration. We use the power of evolution to create and refine these optimized vectors through genetic diversification and then natural selection in vivo.
4D Purpose Statement: Boldly Innovating to Unlock the Full Potential of Gene Therapy for Countless Patients
GUIDING PRINCIPLES
- Dare to Cure - Patients are waiting. Create big dreams for patients and take calculated risks to achieve them
- Break Boundaries - Question the status quo and innovate beyond conventional approaches
- Beyond Yourself - It's about patients, their families, our team, our families. We strengthen each other.
- Prepare and Execute Relentlessly - Start with the end in mind, over-prepare and make contingency plans to your contingency plans
We invite all of you who share our passion and vision in creating the ultimate gene therapy products to cure genetic and rare diseases in children and adults. We seek the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers generous benefits and provides challenging opportunities for career development.
- Website
- http://www.4dmoleculartherapeutics.com/
- Phone
- 510-505-2680
- Location
-
5858 Horton St. Suite 455
Emeryville
California
94608
United States
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