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Senior Scientist, Human Genetics

Employer
Takeda
Location
Boston, Massachusetts
Start date
Oct 6, 2024
View more categoriesView less categories
Discipline
Science/R&D, Biotechnology, Genetics
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Genetown, Best Places to Work

Job Details

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’sPrivacy Noticeand Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as Senior Scientist, Human Genetics in our Cambridge, Massachusetts office. The Human Genetics team in Takeda Research is responsible for generating impactful insights from human genetics data to advance Takeda’s pipeline across Gastrointestinal & Inflammatory diseases, Neurosciences and Oncology disease areas. We are seeking an innovative data scientist with deep knowledge in human genetics and multi-omics to join our team and accelerate drug target discovery.

In this critical role, you will lead human genetics projects from ideation to execution, using publicly available and proprietary data, to advance target identification and validation, safety assessment, and patient stratification. This role’s responsibilities include 1) key contributions to establishing the Human Genetics group strategy, 2) close collaboration with colleagues in various functions across the organization to drive impact and contribute to go-no go decisions across Takeda’s drug discovery and development pipeline, and 3) active contributions to external collaborations to link genetic data to longitudinal phenotypic data from diverse populations. You will be empowered to work closely with disease area leads to identify priorities and design human genetic analyses. This is an amazing opportunity to work in an inclusive and highly collaborative cross-functional workplace driven by one mission: drive the science forward to deliver transformative therapies to patients.

How you will contribute:

ACCOUNTABILITIES

  • Establish an influential and collaborative role within disease-oriented project teams by leading and actively contributing to the design, analysis and interpretation of genetic studies to inform target identification, safety assessment and population stratification in Gastrointestinal & Inflammatory diseases, Neurosciences.
  • Work with a community of statistical geneticists to implement a human genetics roadmap and strategy.
  • Work collaboratively with data scientists and data engineering groups to enhance integrative analytic pipelines
  • Establish and lead external collaborations to implement emerging technologies and/or interrogate relevant biomedical datasets with in-depth genetic and health information

Minimum Requirements/Qualifications:

  • PhD in computational biology, bioinformatics or similar discipline with 2+ years of postdoctoral experience in human genetics research.
  • Deep experience with GWAS/eQTL/pQTL analyses, fine-mapping and colocalization, Mendelian randomization, WES/WGS sequencing data analyses, and rare variants statistical analyses required.
  • Track record experience analyzing genetic data linked to longitudinal real-world health data from large biobanks (e.g. UK Biobank, FINNGEN, Genes and Health, All Of Us, Million Veterans Project etc) required
  • Experience contributing to pre-competitive academic-pharma partnerships preferred.
  • Experience with proteomics (e.g Olink) and/or transcriptomic data analyses desired.
  • Experience with phenotype ontologies, pathway-based approaches, multivariate analyses, polygenic risk score analyses, machine learning desired.
  • Strong scientific understanding of molecular biology and genomics, and ability to interpret genetic findings in disease context
  • Familiarity with pharmaceutical R&D processes and one or more diseases areas of interest of Takeda (neuroscience, gastrointestinal and inflammation) desired
  • Excellent communication, presentation and interpersonal skills
  • Independent, highly collaborative with ability to work in cross-functional and diverse team environment
  • Solid knowledge of Unix, command lines interfaces, and fluency in common scripting and/or programming language (e.g. R, Python, Perl, Java, C/C++)
  • Solid experience with parallel computing and cloud computing required

This position is currently classified as "hybrid" in accordance with Takeda's Hybrid and Remote Work policy.

LOCATION:

Cambridge, MA, USA (hybrid)

Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

133,000.00 - 209,000.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

LocationsBoston, MA

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time

Job Exempt

Yes

Company

For over 240 years, Takeda’s propensity to evolve has driven the next generation of innovation. Today, our organization spans the globe—colleagues across business units and functions face challenges head-on to deliver life-transforming treatments, guided by our commitment to patients, our people and the planet.

As a values-based, R&D-driven biopharmaceutical leader headquartered in Japan, we focus our R&D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. In addition to our R&D efforts, we’re laser-focused on harnessing the power of data, digital, and technology to improve health outcomes for patients across the globe.

 

Since our founding in Japan, integrity and putting patients first have been at the heart of our identity. We're proud of our employees and their commitment to improving the quality of life for patients, and to working with our partners in health care in approximately 80 countries and regions. With each new breakthrough comes opportunities to develop your career, hone new skills, and create a brighter future

For more information, visit https://jobs.takeda.com/

Company info
Website
Location
650 East Kendall Street
Cambridge
MA
02421
United States

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