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Senior Scientist, Molecular Design

Employer
Terray Therapeutics
Location
Remote (United States)
Start date
Oct 4, 2024
View more categoriesView less categories
Discipline
Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time

Job Details

Company Overview: Terray Therapeutics is a venture-backed biotechnology company led by pioneers and long-time leaders in artificial intelligence, synthetic chemistry, automation, and nanotechnology. We’re generating chemical data purpose-built to propel drug discovery into the information age — and we’re doing it on a larger scale and faster than has ever before been possible.

Our closed loop system generates precise chemical datasets at unrivaled scale that work seamlessly with AI to systematically map biochemical interactions between small molecules and causes of disease. Iterative cycles of virtual molecular design and experimentation power AI and machine learning models, which in turn guide the next cycle of design. With a chemistry engine that measures billions of interactions daily and becomes increasingly precise with every cycle, we can answer an unprecedented array of questions — deriving insights that enable us to predictably create drugs for patients in need.

Position Summary: Terray is currently seeking a motivated, creative, and experienced scientist to join our molecular design group. As an integral member of the Computational and Data Sciences (CDS) team, the candidate will guide design efforts to follow up on hits and advance programs into lead optimization, leveraging our vast chemical datasets and proprietary wet-lab + computational platforms to power state-of-the-art small molecule design. In this interdisciplinary role, the candidate will work closely with the chemistry and biology functions at Terray, as well as the machine learning and data science teams within CDS.


The core responsibilities of this position are:

  • Design small molecules with in-house, high-throughput computational tools using both structural models and ligand-based data from our proprietary screening platform

  • Develop strategies to assess and progress hits across multiple programs for our internal pipeline and partnered projects

  • Design focus libraries to drive small molecule programs in hit-to-lead and lead optimization

  • Develop and evaluate models and generative tools to design compounds with desired properties in collaboration with the machine learning team

  • Communicate molecular design strategy and outcomes to teams across the company


Experience and Qualifications: Part of Terray’s success is nurtured by a hands-on work environment where everyone is accountable, vested in a vision of excellence, and actively taking part in the success of the business. Terray supports a positive work environment where employees can feel engaged, recognized and empowered to be creative.

Required Qualifications:

  • BS/MS/Ph.D in computational, organic, or medicinal chemistry, or a related field

  • Experience applying ligand-based and structure-based methods to designing small molecules for multiple drug discovery projects

  • Experience working with medicinal chemists to optimize ADME and safety issues

  • Experience triaging large data sets from virtual screens, DEL screens, and/or HTS

  • Experience with RDKit, molecular simulation suites (Schrodinger, MOE, etc.), and docking programs (AutoDock Vina, rDock, etc.)

  • Proficient in Python and the PyData stack (numpy, pandas, scipy, scikit-learn, etc.)


Compensation Details: $160,000 - $240,000 (annually) depending on seniority; participation in the Company's option plan; 3% retirement safe harbor contribution; fully-paid medical, dental, vision, life and disability benefits.

Company

Terray is a biotechnology company with the technology, data, and mindset to radically change the way we discover and develop small molecule therapeutics. We explore molecules and targets broadly and deeply with a sophisticated integration of ultra-high throughput experimentation, generative AI, biology, medicinal chemistry, automation, and nanotechnology. Everything the company does is grounded in an iterative approach, producing massive amounts of precise, purpose-built data that gets increasingly valuable with each cycle of design and experimentation. The company’s platform uniquely blends experimentation and computation to improve the cost, speed, and success rate of small molecule drug discovery and development.

Company info
Website
Location
750 Royal Oaks, Suite 100
Monrovia
CA
91016
US

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