Advisor - Peptide Phage Display (San Diego, CA)

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

General Description

This is a technical position in the Peptide Discovery Team within Lilly Biotechnology Center in San Diego.  The individual should demonstrate expertise in the peptide phage display platform to lead/support peptide discovery.  The candidate will be an integral part of an innovative and interdisciplinary team that utilizes phage and mRNA display platforms to enable de novo peptide discovery and support peptide optimization at Lilly.  The successful candidate must show a track record of innovation behavior, scientific curiosity, and desire to learn and implement new technologies and platforms. Excellent interpersonal, communication, and organizational skills are required for this position. 

Key objectives and deliverables

Design and perform phage display selections to identify target specific peptide therapeutics Design peptide new libraries and scaffolds for phage display platform Hit characterization and optimization using different display technologies.  The responsibility expands to improving affinity, potency, solubility, and introducing drug-like attributes of therapeutic peptides.  Integrate computational and structure-based information with display technologies for hit-to-lead optimization. Collaborate and effectively communicate with project teams, cross-functional teams, and the Peptide Discovery team members.  Present data on regular basis in various internal meetings Diligently maintain detailed, and well-organized records of experiments using Electronic Notebooks.

Requirements

• Ph.D and/or postdoc in chemical, biological sciences or a related subject OR bachelor or master’s degree in chemical, biological Sciences or related field with a minimum of 6 years of relevant lab-experience

• Deep expertise in the build and execution of cyclic peptide phage display platform in novel peptide hit discovery

Additional Preferences

• Knowledge and experience in peptide chemistry and synthesis

• Knowledge and experience in the use of computational methods during peptide hit-to-lead optimization

• Knowledge with FACS and flow cytometry

• Self-motivated, strong work ethic, independent and results oriented

• Ability to work independently as well as in cross-functional team settings

• Self-driven, imaginative, organized, focused, and able to work as part of a high-performing, high-paced team

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