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Scientist II, Chemistry

Employer
ReCode Therapeutics
Location
Menlo Park, California
Start date
Aug 28, 2024
View more categoriesView less categories
Discipline
Science/R&D, Biotechnology, Chemistry
Required Education
Masters Degree/MBA
Position Type
Full time
Hotbed
Biotech Bay

Job Details

Who We Are:

ReCode Therapeutics is a clinical-stage genetic medicines company using precision delivery to power the next wave of mRNA and gene correction therapeutics. ReCode’s proprietary Selective Organ Targeting (SORT) lipid nanoparticle (LNP) platform enables highly precise and targeted delivery of genetic medicines directly to the organs, tissues and cells implicated in disease, enabling improved efficacy and potency. ReCode’s lead programs include RCT1100 for the treatment of primary ciliary dyskinesia caused by pathogenic mutations in the DNAI1 gene, and RCT2100 for the treatment of the 10-13% of cystic fibrosis patients who have Class I mutations in the CFTR gene and do not respond to currently approved CFTR modulators. RCT1100 and RCT2100 are inhaled disease-modifying mRNA-based therapies formulated using the SORT LNP delivery platform. ReCode is expanding its pipeline to develop potential therapies for other rare and common genetic diseases, including musculoskeletal, central nervous system, liver and infectious disease indications.

Summary of Position:

We are seeking a highly motivated Chemist to expand our next-generation SORT LNP platform. This is an outstanding opportunity for a well-rounded chemistry generalist with a keen scientific aptitude and curiosity coupled with passion for using chemistry to tackle the broadest variety of synthetic challenges to advance our non-viral delivery technology. The successful candidate will be an integral part of enabling targeting of lipid-nanoparticles in support of ReCode’s next generation in vivo delivery platform.

Responsibilities:

  • Design, synthesize, and purify novel chemical compounds including, but not limited to- lipids, polymers, or bioconjugates with minimal supervision
  • Work closely with analytical and formulation scientists to characterize and evaluate compounds for delivery systems
  • Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing guidance and troubleshooting where appropriate
  • May manage one or more direct reports; hire and mentor additions to the team
  • Contribute to novel LNP discovery and formulation, process development, and optimization for in vivo delivery of mRNA, siRNA, gene therapy, and other therapeutic modalities

Qualifications:

  • PhD in Chemistry, medicinal chemistry, chemical or bioengineering, or a related field, and 3+ years relevant post-doctoral experience (biotech/pharma industry preferred).
  • Prior experience in lipid chemistry or conjugation chemistries for drug delivery. Knowledge of NMR, MS, HPLC, TLC, and other common analytical methods
  • Excellent project leadership skills in driving for results and innovation; ability to execute within a matrixed organization
  • Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities
  • Highly collaborative, team-oriented, and considerate of the needs of others
  • Desire to work in a fast-paced environment and contribute to developing the next generation of lipid nanoparticles

Salary Range: 130-135K

 

Benefits Offered for Full-Time Employees: 

  • No premium cost for employees - 100% subsidized by ReCode for full-time employees
  • Company 401k contribution
  • 15 days of company paid holidays, including a holiday shutdown (usually the last week of the year)
  • Mental health support for employees & their families
  • FSA available, including a lifestyle spending account subsidized by company
  • Employee discounts at hotspots

ReCode Therapeutics (www.recodetx.com) offers a competitive compensation/benefits package with a friendly, collaborative culture that values employee engagement and ongoing career development.

ReCode Therapeutics is an Equal Opportunity Employer.

Company

The Why Behind Our Work

We imagine a world where people living with genetic diseases can fully benefit from the promise of genetic medicines. Our novel mRNA and gene correction therapeutics have the potential to make this a reality.

Therapeutic Areas of Focus

Cystic fibrosis

Primary ciliary dyskinesia

Certain cancers and central nervous system (CNS) diseases

Power the Next Wave of Genetic Medicine

We are one of the rare companies whose innovations are poised to fundamentally shift an entire class of medicine.

Join us as we advance our pipeline into clinical development and scale ReCode’s next-generation genetic medicines delivery platform and pipeline.

Company info
Website
Phone
408-585-1700
Location
1140 O'Brien Drive
Menlo Park, CA 94025
US

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