Sr Scientist, In vivo, Obesity, Metabolic & Muscle Diseases

The Obesity, Muscle and Metabolism group at Regeneron is committed to developing transformative medicines to treat obesity, metabolic, endocrine and muscle diseases. We are seeking a Sr. Scientist with solid expertise in integrative metabolism, energy balance and the interconnection between the brain and peripheral organs. The candidate will be responsible for implementing thorough ground-breaking in vivo mechanistic studies for target discovery, validation, and novel therapeutic development.

Independent scientists with a solid expertise of in vivo and ex-vivo neuroscience or metabolism based techniques, molecular biology and biochemistry are encouraged to apply.

As a Sr. Scientist in the Metabolic and Muscle Disease group, a typical day might include the following:

• Planning and conducting in vivo assays including injections, blood collection, metabolic cage assessments, rodent stereotaxic injections and surgeries.
• Establishing and troubleshooting new in vivo models, assays and surgeries
• Planning, initiating, and completing ex vivo brain immunohistochemistry, in situ hybridization, fluorescence and bright field microscopy.
• Supporting and assisting with molecular cloning, RT-qPCR, ELISAs, western blotting, immunoprecipitations, cell culture or single nuclei isolations for RNA-Seq
• Learning new methods and/or technologies relevant to various projects
• Accurately documenting findings and lab records in an electronic laboratory notebook
• Data presentations in formal and informal meetings
• Becoming proficient with the science underlying team projects

This Role Might Be For You If:

• You are organized, determined, team-oriented and productive with confirmed scientific problem-solving abilities
• You thrive in a creative, flexible, team environment.
• You are able to excel in a fast-track environment while contributing to multiple projects
• You enjoy learning and driving ideas and projects forward

To be considered for the Sr. Scientist role, you will have a B.Sc. with at least 8+ years of research experience, in Neuroscience, Metabolism, Physiology or related field. Strong solid hands-on experience with mouse handling, injections and blood collection as well as expertise in vivo neuroscience-based approaches including stereotaxic surgeries, optogenetics, and/or in vivo assessment of metabolism is essential. Research experience with brain IHC/ISH, neuronal culture, single-nuclei RNASeq and/or spatial transcriptomics is desirable. Broad experience in molecular biology, biochemistry, flow cytometry, and in vitro and ex-vivo assays are an asset. Excellent written and presentation skills are essential.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)