Postdoctoral Fellow Membrane protein structure and function (inflammation and rare diseases)

HOW MIGHT YOU DEFY IMAGINATION?

Youve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.

Postdoctoral Fellow - Membrane Protein Structure & Function (inflammation and rare disease)

What you will do

Lets do this. Lets change the world. In this vital role you will perform independent research projects on the molecular mechanism of key membrane proteins involved in inflammatory and rare diseases as part of a highly motivated team of immunologists, structural biologists and critical thinkers. This is a unique opportunity to be part of Amgens R&D Postdoc Program in Inflammation Discovery Research located at the research site in South San Francisco, California. The postdoc will join the labs of Dr. Fei Li (Senior Scientist, structural biology) and Dr. Zhifei Shao (Principal Scientist, inflammation Research), in the department led by Dr. Mark Wilson (Executive director, inflammation Research) and Dr. Menno Van Lookeren Campagne (VP, Inflammation Research), amongst other leading scientists in the fields of immunology and structural biology.

We are hiring a highly motivated postdoctoral fellow to perform independent research projects on the molecular mechanism of key membrane proteins involved in inflammatory and rare diseases as part of a highly motivated team of immunologists, structural biologists and critical thinkers.

The positions are for 2-4 years depending on time to complete projects. Successful candidates will have access to Amgens cutting-edge technologies and innovation and be expected to make exciting scientific contributions to the field, present at scientific conferences and publish their work. Postdocs will be a part of the broader R&D Postdoc Program that focuses on training the next generation of industry scientists. An overwhelming majority of our postdocs go on to advance their careers in industry at leading pharma and biotech companies, including many at Amgen.

We are looking for highly talented, self-motivated individuals passionate about science and making high impact discoveries to work on molecular pathways in inflammatory diseases and rare diseases. A major focus will be on the structure and function of key membrane proteins involved in lysosomal biology. New postdoctoral fellows will take a multi-disciplinary approach combining structural biology, biochemistry (~50%) and cell biology, molecular biology (~50%) to carry out these studies.

• Independent research projects with focus on inflammatory and rare disease

• Work with team of immunologists and structural biologists

• Present discoveries at scientific conferences and publish your findings

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a scientist with these qualifications.

• PhD at the time of appointment

• PhD in biochemistry, biophysics, structural biology, molecular biology, or cell biology with prior research experience in membrane protein, lysosomal biology or immunology.

• Record of independent critical thinking and the ability to design, execute, and interpret experiments, as exemplified by first author high-quality publications.

• Expertise with protein expression/purification, membrane protein, single particle cryo-EM, cell culture, and computational skills are also preferred.

• Broad knowledge and technical competency of molecular and cellular biology; good understanding of enzymology and protein biochemistry; ability to learn new methods/tools as required by the projects.

• Excellent organizational, interpersonal and communication skills.

• Attention to details, good recording keeping, and adherence to deadlines.

• A passion to explore the unknown and make discoveries that will chart new areas of biology.

Please see representative publications from Drs. Fei Li, Zhifei Shao, Mark Wilson and Menno Van Lookeren Campagne:

• Nat Commun. 2024, 25;15(1):5388
• Sci Transl Med. 2022 Apr 20;14(641)
• Sci Transl Med. 2022 Jan 12;14(627)
• Curr Opin Struct Biol. 2022 Aug;75:102399
• Proc Natl Acad Sci U S A. 2021 Jan 19;118(3)
• Science 2020, 368(6493):893-7
• PLoS Pathog. 2017 Jul 31;13(7)
• J Exp Med. 2017 Jun 5;214(6):1809-1826
• Science 2015, 30;347(6221):555-8.
• J Thromb Haemost 2015 Jun;13(6):1090-102
• Nature 506 (2014), 456-62
• J Bio Chem 2014 Sep 26;289(39):27146-27158
• J Exp Med 2010 Jan 18;207(1):7-16
• Cell 2006 Mar 10;124(5):915-27
• Nature 444, 217220 (2006)

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans and bi-annual company-wide shutdowns

• Flexible work models, including remote work arrangements, where possible

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

careers.amgen.com

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.