Sr. Scientist, ADME (Contractor)

Sutro Biopharma, Inc. is seeking a highly motivated and experienced senior Senior Scientist (contract) to join its Preclinical Development team based in South San Francisco, CA. The successful candidate will be responsible for independently devising and executing stage appropriate in vitro ADME and biotransformation strategies, developing LC-MS/MS methods for small molecule and ADC quantification as well as LC/MS-based methods for in vitro and in vivo metabolite/catabolite identification and profiling.  This position is for a 12-month duration with a possible extension based on business needs.Responsibilities: 

• Identify key questions and implement as appropriate in vitro ADME and biotransformation assays to advance molecules from early concept through lead optimization to IND enabling studies
• Conduct literature search, adopt new technologies, and apply critical thinking to address the new scientific challenges with high independence
• Perform metabolite/catabolite identification and profiling in the biological matrices from non-clinical/clinical studies of antibody-drug conjugates (ADCs) using high-resolution mass spectrometry
• Conduct in vitro ADME assays including but not limited to enzymatic payload release, metabolic stability studies in biological matrices (hepatocytes, microsomes, blood, plasma etc.), blood-to-plasma partitioning, and plasma protein binding
• Develop stage appropriate LC-MS/MS methods to quantify small molecule payloads and linker-payloads in biological matrices
• Assess drug-to-antibody ratio (DAR) stability both in vitro and in vivo
• Analyze, interpret, and summarize data to understand metabolic/catabolic pathways, and present findings to multi-disciplinary project teams

Qualifications: 

• Ph.D. in the field of DMPK, analytical chemistry or related areas with a minimum of 8+ years of relevant industry experience (biologics & small molecules).
• Exceptional non-PhDs with demonstrated capabilities and/or significant experience (12+ years) may also be considered
• Demonstrated ability to independently establish new experimental protocols using novel methods or techniques
• In-depth knowledge and experience with in vitro ADME assay design, execution, and data interpretation
• Proven track record of hands-on experience with metabolite/catabolite identification in biological matrices
• Strong background on LC-MS operation and troubleshooting including both Triple Quad and High-Resolution Mass Specs (hands-on experience with SCIEX 7500 QTrap and 7600 QToF is preferred)
• Working experience with ADC is a plus
• Excellent verbal and written communication, problem solving, and critical thinking skills
• Ability to work in a fast-paced and team-oriented environment with flexibility

 Sound exciting? Apply today and join our team! Sutro Biopharma, Inc. requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment.  As required by applicable law, Sutro will consider requests for reasonable accommodations. As an equal opportunity employer, we believe in fostering a culture that is inclusive and values diversity in background and opinions. Sutro Biopharma hires extraordinary individuals into every position in the company and is committed to the diversity of our team. Our company progresses without regard of race, ethnicity, gender, sexual orientation, religious belief, age, disability, or citizenship status. We are dedicated to creating a safe environment where our employees can grow and succeed together. We look forward to hearing from candidates who are interested in exploring opportunities with Sutro! Our People & Culture team/hiring managers are unable to respond and do not accept solicitations from third-party agencies. The anticipated salary range for fully qualified candidates applying for this role at Sutro Biopharma’s California based locations will be $175,000 - $195,000. The final salary offered will be dependent on several factors that include and are not limited to relevant previous experience, job responsibilities and duration of experience, the type and length of experience within the industry and education.   About Sutro Biopharma  Sutro Biopharma, Inc., is a clinical-stage company relentlessly focused on the discovery and development of precisely designed cancer therapeutics, transforming what science can do for patients. Sutro’s fit-for-purpose technology, including cell-free XpressCF®, provides the opportunity for broader patient benefit and an improved patient experience. Sutro has multiple clinical stage candidates, including luveltamab tazevibulin, or luvelta, a registrational-stage folate receptor alpha (FolRα)-targeting ADC in clinical studies. A robust pipeline, coupled with high-value collaborations and industry partnerships, validates our continuous product innovation. Sutro is headquartered in South San Francisco. For more information, follow Sutro on social media @Sutrobio, or visit www.sutrobio.com.