Senior Scientist I/II - Genome Editing Technology

OPPORTUNITY
Mammoth’s Editing Technologies team is hiring a Sr. Scientist I/II to play a lead role in the development of a next-generation genome editing platform. The successful candidate will optimize the platform technology for efficacy and specificity in mammalian cells to enable in vivo editing of various therapeutic targets. This is a fantastic opportunity to impact human health by making CRISPR tools that cure genetic disease.

KEY RESPONSIBILITIES

• Plan, design and execute experiments for CRISPR tool development projects
• Design and produce DNA and RNA-based reagents for genome editing experiments in human cells
• Contribute creatively to seed innovation projects through literature review and shape execution tactics
• Provide instruction to junior team members
• Document experiments in electronic laboratory notebooks
• Present experimental results at internal meetings
• Disclose inventions to the IP team for patenting
• Other duties as assigned

REQUIRED QUALIFICATIONS

• PhD in Molecular Biology, Biochemistry, Biomolecular Engineering or a related discipline; +3 years of relevant professional experience in industry or academia, following completion of PhD
• At least 1 year of experience developing novel CRISPR tools for gene editing in mammalian cells
• Expertise in NGS assays and flow cytometry as readouts for gene editing
• Experience in optimizing RNA and DNA transfections of mammalian cells in a high-throughput setting

PREFERRED QUALIFICATIONS

• Experience with reverse transcriptase (RT) editing
• Experience in developing new assays to assess gene editing outcomes in both replicating and non-replicating cell types
• Experience designing and implementing directed evolution approaches for gene editing improvements 
• Experience managing junior staff
• Working proficiency with common bioinformatics tools (Benchling, JMP, SQL, R, Python)

BENEFITS

• Company-paid health/vision/dental benefits
• Unlimited vacation and generous sick time
• Company-sponsored meals and snacks
• Wellness, caregiver and ergonomics, mental health and education benefits
• 401(k) with company matching

Base Salary Range: $ 150,000 - $182,350

Actual base salary will be determined by relevant professional experience, applicable skills, and internal equity.


Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Mammoth Biosciences requires that all employees be vaccinated against COVID-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.