Manager, Accounting Operations

Position Overview:

The Finance team at Inozyme Pharma is seeking an energetic, highly motivated, and experienced accounting professional to fill a critical role responsible for daily financial operations, managing the monthly close process and responding timely to audit requests.  Reporting to the Senior Manager, Accounting and Reporting, the successful candidate possesses strong analytical and collaboration skills, and is comfortable respectfully challenging the status quo, always looking for opportunities for improvement

Reporting Relationship: This position will report to the Head, Finance & Accounting

About Inozyme Pharma:

Inozyme Pharma is a pioneering clinical-stage biopharmaceutical company dedicated to developing innovative therapeutics for rare diseases that affect bone health and blood vessel function. We are experts in the PPi-Adenosine Pathway, where the ENPP1 enzyme generates inorganic pyrophosphate (PPi), which regulates mineralization, and adenosine, which controls intimal proliferation (the overgrowth of smooth muscle cells inside blood vessels). Disruptions in this pathway impact the levels of these molecules, leading to severe musculoskeletal, cardiovascular, and neurological conditions, including ENPP1 Deficiency, ABCC6 Deficiency, calciphylaxis, and ossification of the posterior longitudinal ligament (OPLL).

Our lead candidate, INZ-701, is an ENPP1 Fc fusion protein enzyme replacement therapy (ERT) designed to increase PPi and adenosine, enabling the potential treatment of multiple diseases caused by deficiencies in these molecules. It is currently in clinical development for the treatment of ENPP1 Deficiency, ABCC6 Deficiency, and calciphylaxis. By targeting the PPi-Adenosine Pathway, INZ-701 aims to correct pathological mineralization and intimal proliferation, addressing the significant morbidity and mortality in these devastating diseases.

Essential Duties and Responsibilities:

• Ensure the smooth execution of monthly and quarterly closing processes to drive timely financial reporting, including the preparation and review of journal entries, as well as the scrutiny of balance sheet reconciliations, while aligning with U.S. GAAP and Company standards
• Prepare and review journal entries, provide appropriate support, and resolve all reconciling items for each accounting period
• Partner with department heads to review and conclude on monthly accruals
• Manage and prepare payroll utilizing ADP
• Ensure accurate and timely recording of payroll to the G/L, including month-end and quarter-end payroll and benefits accruals
• Analyze and provide commentary on the balance sheet and income statement variances
• Assist with the preparation of monthly and ad-hoc reporting for senior management
• Assist with preparation of various financial statement disclosures and supporting documentation for our quarterly and annual SEC filings
• Assist with maintenance of internal control framework and associated documentation requirements

• Collaborate with accounting team to support external audits and assist with the preparation of workpapers in advance of audits
• Recommend and manage the implementation of new accounting standards, and best practices regarding policies and procedures
• Take a lead role in special projects focused on improving the quality and efficiency of accounting processes, particularly to streamline and shorten the close process
• Assist in the implementation of new financial systems, as needed
• Manage additional projects and requests, as needed

Educational Qualifications: Bachelor’s or Master’s degree in Accounting required; CPA preferred

Additional Qualifications:

• Experience working for an early to mid-stage biotech company required
• 5+ years of experience in accounting, preferably with public accounting experience
• Strong knowledge of fundamental accounting principles, including U.S. GAAP and SOX 404 requirements
• Ability and willingness to meet business critical deadlines
• Ability to work collaboratively and effectively with others and a strong desire to make a positive impact
• Highly organized and detail-oriented, with strong problem-solving and communication skills, including the ability to translate financial concepts to individuals outside of Finance
• Motivated and flexible team player with the ability to wear multiple hats and prioritize tasks in a fast-paced, deadline-driven environment
• Ability to identify inefficiencies, provide suggestions, and drive positive change
• Experience working in a full-scale ERP system, and the ability to quickly learn and understand various financial accounting systems. Experience with systems such as NetSuite, Concur, ADP, Shareworks, and ActiveDisclosure a plus