Principal Scientist, Immuno-Oncology

The Immunology & Inflammation department is seeking a skilled and ambitious Ph.D. scientist with solid background in tumor immunology and/or autoimmunity to contribute to the discovery and development of novel therapeutics in the Cancer Immunology group at Regeneron. You will be responsible for designing and executing a variety of cell-based immunological assays and in vivo experiments using tumor and autoimmune mouse models. The successful candidate will be a member of a dynamic and creative team utilizing cutting edge technologies to address outstanding questions in the field of cancer immunology and autoimmunity.

Please see our relevant published work:

Waite JC et al., Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed.aba2325

Skokos D et al., Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed.aaw7888

As a scientist in the Cancer Immunology team, activities include the following:

• Develop, optimize, and perform a variety of immunoassays to evaluate the impact of therapeutic candidates on immune cell function and phenotype including advanced techniques such as multicolor flow cytometry and fluorescence microscopy.
• Independently plan and execute in vivo studies using tumor and autoimmune mouse models. These will include therapeutic treatment with injections through various routes (IP, IV, SC), blood and tissue collection for downstream analysis of immune responses.
• Analyze data using biological and statistical software such as OMIQ, Prism, Excel, etc.
• Work collaboratively with cross functional scientists to drive target validation and therapeutic antibody development.
• Delivering impactful presentations to colleagues, including senior leadership.
• Writing protocols and study reports, maintain accurate electronic records.
• Routinely review relevant literature, attend scientific meetings, and maintain expertise in the field of Immunology and Immuno-Oncology
• Training and management of research associates as needed.

This role might be for you if:

• You are excited about developing immunotherapies to promote a tumor specific and durable immune response to eradicate cancer.
• You can innovate and lead new scientific directions.
• You are a strong team player with a collaborative spirit.
• You have excellent oral and written communication skills.
• You can independently design and execute experiments, analyze data, and interpret results.
• You can multitask and manage multiple projects simultaneously.

This role requires a Ph.D. in immunology, immuno-oncology or related field with a strong record of innovation and publication and 5+ years of experience. Proven expertise in T cell biology with experience using mouse tumor and autoimmune models including high dimensional immunophenotyping is required. Proficiency with fluorescence microscopy and advanced imaging techniques is a plus.

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)