Senior Research Associate, ADME (Contractor)

Sutro Biopharma, Inc. is seeking a highly motivated and experienced contractor to join its Preclinical Development team based in South San Francisco, CA. The individual will be responsible for conducting in vitro ADME experiments, developing quantitative LC-MS/MS methods for small molecule and ADC quantifications as well as qualitative LCMS methods for metabolite/catabolite identifications in vitro and in vivo. This position is for a 12-month duration with a possible extension based on business needs. Responsibilities: 

• Develop stage appropriate LC-MS/MS methods to quantify small molecule payloads and linker-payloads in biological matrices.
• Conduct in vitro ADME experiments including but not limited to enzymatic payload release, metabolic stability studies in biological matrices (hepatocytes, microsomes, blood, plasma etc.), plasma/blood partitioning, and plasma protein binding according to defined protocols under general guidance.
• Identify small molecule metabolites and ADC catabolites using high-resolution mass spectrometer in support of non-clinical or clinical studies.
• Assess drug-to-antibody ratio (DAR) stability both in vitro and in vivo.
• Analyze, interpret, and summarize data to understand metabolic/catabolic pathways, and present findings to project teams.

 Qualifications: 

• BS or MS in the field of DMPK, analytical chemistry or related with a minimum of 5+ (for BS) or 1+ (for MS) years of relevant industry experience.
• Demonstrated ability to conduct in vitro ADME assays following the established protocols.
• Strong background on LC-MS operation including both Triple Quad and High-Resolution Mass Specs (hands-on experience with SCIEX 7500 QTrap and 7600 QToF is preferred)
• Working experience with ADC is a plus.
• Excellent communication skills and a team player mindset.

 Sound exciting? Apply today and join our team! Sutro Biopharma, Inc. requires all new hires to be fully vaccinated for COVID-19 prior to the first date of employment.  As required by applicable law, Sutro will consider requests for reasonable accommodations.Sutro provides a competitive benefits package that includes a choice of health, dental, and vision insurance, life insurance, flexible spending accounts, 401K plan, PTO, ESPP (Employee Stock Purchase Plan) and stock options.As an equal-opportunity employer, we believe in fostering a culture that is inclusive and values diversity in background and opinions. Sutro Biopharma hires extraordinary individuals into every position in the company and is committed to the diversity of our team. Our company progresses without regard of race, ethnicity, gender, sexual orientation, religious belief, age, disability, or citizenship status. We are dedicated to creating a safe environment where our employees can grow and succeed together. We look forward to hearing from candidates who are interested in exploring opportunities with Sutro! Our People & Culture team/hiring managers are unable to respond and do not accept solicitations from third-party agencies. The anticipated salary range for fully qualified candidates applying for this role at Sutro Biopharma’s California-based locations will be $110,000 - $140,000 (not including benefits). The final salary offered will be dependent on several factors that include and are not limited to relevant previous experience, job responsibilities and duration of experience, the type and length of experience within the industry and education.