Scientist I / Senior Scientist – Immunology

Position

We are seeking a highly skilled and motivated immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of immunology and oncology. This individual will work closely with our drug discovery project teams on optimization and characterization of novel compounds to evaluate their impact on immune cells and disease-relevant biology. The candidate must be self-driven, organized, able to work well with other scientists, and able to thrive in an exciting environment in a dynamic company.

Qualifications

• Ph.D. in immunology, biomedical sciences, cancer biology, or related field with 0-2 years industry experience (Scientist I), 3-4 years of industry experience (Scientist II), or 5-6 years of industry experience (Senior Scientist). M.S. with additional industry experience will also be considered.
• Research experience in the field of immunology, experience with B cells and myeloid cells is a plus.
• Expertise in functional assays measuring cellular activation, differentiation, cytokine release, proliferation, and migration.
• Hands on experience in development, optimization and execution of high-dimensional flow cytometry to phenotypically characterize immune cells including both surface and intracellular staining, primary cell isolation, ELISA, western and multiplexing technologies.
• Background in cellular signaling or ubiquitin biology is a plus.
• Develop novel ideas/technologies, eager to learn, innovate.
• Propose and implement resolutions to technical problems/issues.
• Work with departmental and/or cross functional peers to execute on assignments.
• Senior Scientist: experience leading preclinical drug discovery project teams and/or writing IND reports is a plus.

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative; solutions and results-oriented focus

Strong scientific curiosity and initiative; hands-on and resourceful

Self-driven and enthusiastic with the ability to thrive in a dynamic environment

Company

Nurix, Inc. is a science-minded, goal-oriented organization that is focused on bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the protein degradation machinery of the cell. The Nurix scientific team has established an innovative drug discovery platform based on recent advances in understanding of the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas.

Nurix’s Protein Regulation Platform enables the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. Nurix entered into an exclusive collaboration with Sanofi and Gilead for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. 

Nurix was founded by internationally recognized experts in the ubiquitin proteasome field and is funded by leading life science investors, Third Rock Ventures and The Column Group. The company is headquartered in San Francisco, California

Application Process

Please apply by sending your CV to http://www.nurix-inc.com/careers/.

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