DEL & Protein Sciences Internship - Contract

Position

We are seeking a skilled and motivated Scientist to join Nurix’s DEL & Protein Sciences team. Nurix is devoted to unlocking the therapeutic potential of the ubiquitin proteasome system (UPS) in the areas of oncology and immuno-oncology, by utilizing the mechanistic and structural insights to guide drug discovery efforts. The successful candidate will provide hands-on experience in Nurix’s protein production efforts to support biochemical, biophysical and structural efforts.  In this position, the candidate will be focusing on running and improving a high-through protein expression screening platform.  An opportunity to screen protein drug discovery targets using DNA Encoded Library technology (https://www.nurixtx.com/platform/) can be provided depending on interest.  This individual will work closely with an experienced team of interdisciplinary scientists and have opportunities to present findings to the project team. The candidate should have a strong desire to learn new techniques and the ability to incorporate new methodologies into their work. The ideal candidate will be self-driven, resourceful, organized, focused, and enjoy working in a dynamic team environment driven to deliver quality proteins to enable existing drug discovery platforms.

Rate & Duration

The pay rate is $25/hr.  Minimum of 20h per week, ideally 40h per week.

Required Qualifications

• Enrollment in Undergraduate degree program in Biophysics, Biochemistry, Cell and Molecular Biology or related field.
• Good understanding of protein overexpression in bacterial, insect or mammalian expression systems.
• Knowledge of protein purification techniques including but not limited to affinity chromatography, SEC, Ion-Exchange chromatography.
• Previous experience in a research laboratory setting (academic or industry).
• The candidate should be enthusiastic, driven, have the ability to work independently in a team environment and thrive in a dynamic start-up environment.
• The successful candidate will be aligned to Nurix’s culture and values; he/she will be team oriented and highly collaborative with a hands-on approach.

Preferred Qualifications 

• Undergraduate degree in Biophysics, Biochemistry, Cell and Molecular Biology or related field.
• General interest in platform automation.
• Hands-on experience with screening assays (e.g. HTS).
• Hands-on experience with High-throughput protein expression in bacterial, insect or mammalian expression systems,
• Knowledge in the operation of protein purification instrumentation (e.g. AKTA, ultracentrifugation),
• Hands-on experience on purification of proteins from bacterial, mammalian or insect expression systems for structural and functional applications.
• General knowledge of immuno-oncology, structural biology, and drug discovery, or
• General knowledge of protein ubiquitylation biochemistry and pathways.

Application Process

• Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.
  

  Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.