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Sr. Scientist, Analytical Development for Raw Materials

Vaxcyte, Inc.
San Carlos, California
Start date
Jun 19, 2024

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Job Details

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. 

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*MODEL EXCELLENCE:  The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.
Vaxcyte is looking for an energetic and talented individual to join our analytical development team. Primary responsibility for the incumbent will include method development, sample testing and data analysis, protocol and report authorization, and analytical method transfer oversight and coordination. 
Essential Functions:
    • Independently perform method development across a broad range of analytical methods for raw materials for QC and characterization purpose to support pre-clinical and clinical projects.
    • Oversee method transfer to external contract testing labs; Design and perform studies to assist troubleshooting of QC testing, method qualification/validation or issues related to the methods as needed.
    • Perform analytical testing, data analysis and interpretation and present in various project and functional team meetings.
    • Collaborate with cross-functional teams to achieve project timelines and goals.
    • Maintain thorough and accurate records of laboratory work.
    • Author analytical documents including but not limited to test method, protocols, and reports.

    • PhD in Analytical Chemistry, Biochemistry or a related field with 3+ years of industry experience; MS or BS with 8+ years of industry experience in Pharma/Biotech.
    • Extensive hands-on experience in a wide range of analytical techniques, such as UV-Vis,  HPLC, CE, SDS-PAGE, icIEF, LCMS, GCMS, enzyme kinetics, colorimetric and fluorescent plate-based assays, ELISA, Western Blot, etc.
    • Adeptness in learning: given the broad range of molecular structures and analytical methods involved, the ability to quickly learn and adapt to new techniques and technologies is paramount.
    • Ability to analyze complex problems, identify potential solutions, and make informed decisions is critical for the success of this role.
    • Familiar with regulatory standards and quality systems (e.g., GLP, GMP).
    • Ability to work in a fast-paced team environment, and to consistently meet aggressive timelines while prioritizing tasks for multiple projects.
    • Must communicate complex scientific concepts clearly and precisely to a variety of audiences, including junior scientists, cross-functional teams, and non-scientific stakeholders.
    • Effective communication and interpersonal skills, with the ability to collaborate cross-functionally and work effectively in a team environment.
    • This position is a lab-based role and requires onsite presence.

Reports to: Associate Director, Analytical Development, Raw Materials
Location: San Carlos, CA
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $152,000 – $170,000


Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease.

Company info
(650) 837-0111
825 Industrial Road, Suite 300
San Carlos

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