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Associate Scientist II, Analytical Development for Characterization

Employer
Vaxcyte, Inc.
Location
San Carlos, California
Start date
Jun 18, 2024

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Job Details

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance. 

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*MODEL EXCELLENCE:  The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.
 
Summary:
 
Vaxcyte is looking for an energetic and talented individual to join our Analytical Development team. Primary responsibility for the incumbent will be to support the developmental activities currently on going in the laboratory as assigned.
Essential Functions:
    • Assist in the design, execution and interpretation of experiments to analyze drug substances and intermediates such as proteins and carbohydrates including:
    •    Microplate assays including enzymatic assays.
    •    HPLC- Especially SEC and RP-HPLC with experience in Chemstation.
    •    CE and iCIEF – Especially with Protein Simple or PA-800 systems.
    • Assist in analytical method development of new assays.
    • Keep accurate and detailed records of experiments.
    • Summarize data and communicate to analytical team.
    • Support daily lab operations, sample inventory and sample shipment.
    • Work within a team environment and provide support to further team objectives.
    • Complete any assigned tasks in high quality and in a timely manner.

Requirements:
    • BS in Chemistry, Analytical Chemistry preferred, Organic / Biochemistry considered, with 2-6 years of relevant industry experience or MS with 1-4 years.
    • Ideal candidate will have a background in analytical chemistry principles and hands-on experience with modern analytical instrumentations commonly used in the analysis and characterization of drug candidates. Candidates with other scientific disciplines may be considered based on relevant experience.
    • Experience in chemical and biological assays such as colorimetric/fluorometric microplate assays and HPLC.
    • Experience working with protein analysis – UV-Vis, CE, BCAs etc.
    • Experience working with carbohydrate analysis and SEC-MALS a plus.
    • Understanding of basic principles of analytical method development/ validation/ qualification concepts.
    • Attention to detail and excellent skills in record keeping / documentation. Critical thinking and ability to analyze data.
    • Strong interpersonal skills: ability to communicate effectively both verbally and in written formats.
    • Ability to work under supervision and independently in a fast-paced, cross-functional environment and collaborate effectively with other team members. Eagerness and ability to learn and understand new concepts with ease.

Reports to: Manager, Analytical Development
 
Location: San Carlos, CA
 
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
 
Salary Range: $105,000 – $114,000
 

Company

Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease.

Company info
Website
Phone
(650) 837-0111
Location
825 Industrial Road, Suite 300
San Carlos
CA
94070
US

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