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Senior Associate Scientist, Mammalian Cell Transfections (Contract)

Employer
Life Edit Therapeutics
Location
Durham, NC
Start date
Jun 12, 2024

View more

Discipline
Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Bio NC

Job Details

 

The Role:

Life Edit is seeking a scientist knowledgeable in genome editing technologies and skilled in mammalian cell culture to be part of a highly collaborative team focused on advancing Life Edit’s RNA-guided editing systems. As a member of Lead Development, the selected candidate would work to develop and characterize gene editing programs targeting diseases to transition these programs from research to preclinical evaluation and clinical advancement. A successful candidate will join our team and make significant contributions that support both internal and external programs.

 Here’s What You’ll Do:

  • Evaluate and optimize Life Edit gene editing systems in mammalian cells to select optimal systems for further therapeutic discovery and development
  • Maintain cell culture of various mammalian cell lines
  • Execute mammalian cell transfections to assess gene editing systems using high throughput screening
  • Perform cell-based assays by which to evaluate Life Edit’s genome editors
  • Design and execute experiments in a timely and independent manner
  • Maintain meticulous records of experimental methods, tool development, and protocols
  • Work with a collaborative team to troubleshoot experimental procedures

Requirements:

  • Bachelor’s degree with 2+ years, or Master’s degree with applicable experience in Biology, Biochemistry, Chemistry, or a related field
  • Expertise in culturing, transfecting, and analyzing mammalian cells—primary cell culture experiment a plus
  • Experience using cell-based assays such as flow cytometry, ELISAs, and viability assays
  • Experience with molecular biology techniques including PCR, cloning, DNA/RNA extraction and purification, and NGS library preparation
  • Prior experience with CRISPR systems and familiarity with NGS techniques and automation is advantageous
  • Demonstrated ability to work independently as well as collaboratively in a team-oriented environment

 

Why join Life Edit and the ElevateBio ecosystem?

Life Edit Therapeutics is an integrated subsidiary of ElevateBio, a technology-driven cell and gene therapy company that is accelerating access to the cutting-edge technologies and expertise that can change the future of medicine. Our integrated model combines multiple R&D technology platforms – including Life Edit gene editing – and cGMP manufacturing to power the discovery and development of advanced therapeutics. Our ecosystem is designed to enhance speed, delivery, and probability of success to change patient lives.

Life Edit is an integral part of ElevateBio’s ecosystem of platform technologies and is pioneering focused next-generation gene editing technologies and therapeutics. Located in Durham, NC, members of Life Edit work closely with the ElevateBio Research and Development and BaseCamp manufacturing teams in Waltham, MA. Life Edit is advancing therapeutic programs in collaboration with industry partners while building its own internal pipeline of gene editing therapies. We are looking for a unique individual who can continue to lead the cultural development of Life Edit and build on its momentum as an integral part of the ElevateBio ecosystem.

Our Mission:
To power the creation of life-transforming cell and gene therapies, at a speed the world deserves.

Our Vision:
We seek to be the world’s most indispensable cell and gene therapy technology company, redefining how companies operate, how products are created and how disease is treated.

ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Company

Life Edit Therapeutics is an ElevateBio company focused on advancing next-generation gene editing technologies and therapeutics. Life Edit has built a highly innovative platform with one of the world’s largest and most diverse libraries of RNA-guided nucleases (RGNs), base editors, and reverse transcriptase (RT) editors that provide flexible editing and unprecedented access to the genome. The platform allows Life Edit to target any genomic sequence and potentially develop novel human therapeutics for the most challenging genetic diseases by enabling ex vivo engineering for cell therapies and regenerative medicines and in vivo delivery of gene therapies.

Company info
Website
Location
300 Morris Street, Suite 300
Durham
NC
27701
US

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