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Flow Cytometry, Clinical Biomarkers- Principal Scientist

South San Francisco, California
Start date
Jun 11, 2024

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Job Details


If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. Its time for a career you can be proud of.

Flow Cytometry, Clinical Biomarkers - Principal Scientist


What you will do

Lets do this. Lets change the world. In this vital role you will design, develop and implement clinical biomarker assays employing innovative flow cytometry methods and techniques to support our drug development efforts.

  • Provide technical oversight for the development and execution of clinical cytometry assays to support programs across multiple therapeutic areas,

  • Collaborate with stakeholders within the Department of Clinical Biomarkers and Diagnostics and across other functional areas

  • Develop and qualify complex biomarker assays to support various clinical programs

  • Supervise/mentor staff

  • Provide innovative approaches to address biological questions, analyze and interpret data, present results and work with internal and external partners to develop and implement biomarker assays.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek will possess these qualifications.

Basic Qualifications:

Doctorate degree and 2 years of scientific/technical experience


Masters degree and 5 years of scientific/technical experience


Bachelors degree and 7 years of scientific/technical experience

Preferred Qualifications:
  • A strong background and experience in multiparametric flow cytometry assays including immunophenotyping, receptor occupancy and immune based functional assays are required for this position.

  • Candidate should be able to independently initiate and drive projects and contribute intellectually to support the work of others.

  • Supervisory and mentoring experience in a lab setting.

  • Ability to analyze and interpret data to assist in assay validation, development, and troubleshooting.

  • Ability to multi-task and manage multiple projects, strong verbal and written communication skills with a high degree of motivation, creativity and collaborative qualities.

  • Previous experience working in a matrixed environment to implement flow cytometry assay development and validation to support clinical trials.

  • Project management skills to meet critical timelines associated with various activities necessary to support biomarker assessment of clinical samples.

  • Demonstrated track record of critical independent thinking and troubleshooting ability and innovative ways to solve complex questions is highly desirable.

  • Understanding of disease biology and biomarker approaches in multiple therapeutic areas.

  • Knowledge of Good Clinical Practice (GCP) guidelines is required.

  • Work and coordinate with internal stakeholders as well as external partners such as CROs and vendors to support outsourced activities.

  • Familiarity with processes and factors needed to evaluate and qualify CROs.

  • Experience interfacing with CROs to coordinate data and assay transfers, and real time monitoring of assay performance.

  • Familiarity with flow cytometry data qc processes.

  • Experience with complex data analysis software for flow cytometry such as FlowJo, FCS Express, OMIQ.AI, SPADE, viSNE and CITRUS


What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

  • Stock-based long-term incentives

  • Award-winning time-off plans and bi-annual company-wide shutdowns

  • Flexible work models, including remote work arrangements, where possible

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.


We are all different, yet we have this in common: our mission to serve patients. This sense of shared purpose is key to our becoming one of the world’s leading biotechnology companies. It guides us as we continue to launch new medicines and reach millions of patients worldwide.

We live the mission.

We win together.

We thrive on continual challenge.

Our team of 22,000+ scientists and professionals worldwide bring distinct perspectives and experiences to all we do. We leverage our global talent to achieve together—to research, manufacture and deliver ever-better products and greater depth to our mission.

At Amgen, there is a strong correlation between our high level of diversity and performance. Because addressing issues with a wider range of perspectives and approaches leads to more creative problem-solving. Together, we’re transforming the promise of science and biotechnology into therapies that have the power to restore health.

Connect with us to explore how you can Win, Live, and Thrive at Amgen.

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Company info
Corporate Headquarters
One Amgen Center Drive
Thousand Oaks

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