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Director, Clinical Science

Maze Therapeutics
South San Francisco, CA
Start date
Jun 4, 2024

View more

Clinical, Clinical Research
Required Education
Masters Degree/MBA
Position Type
Full time
Biotech Bay

Job Details

The Position: 

At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Director, Clinical Science to join our Clinical Science team and take a central role in pioneering the future of healthcare.   

As  a Director, Clinical Science, you'll be at the forefront of translating genetic insights into innovative treatments for patients. Your work will help drive the clinical development programs for game-changing therapies, starting with a small molecule that targets APOL1 – a key genetic driver of chronic kidney disease.  

But that’s not all.  Maze Therapeutics has an exciting pipeline focused on renal, cardiac, and metabolic diseases, including a second precision medicine for kidney disease that is following closely behind APOL1. In short, you'll play a fundamental part in advancing medical breakthroughs that have the potential to transform many lives.  

To succeed in this role, you'll need to thrive in a fast-paced, collaborative environment. As a Director, Clinical Science for one or more development programs, you will partner closely with cross-functional team members and other technical experts to help design, conduct, and interpret the key clinical studies, including first-in-human and proof-of-concept trials. Your contributions will be highly visible and integral to the success of the Maze team. 

Your Impact: 

  • Lead in the design, execution, and analysis of clinical trials for clinical stage assets at Maze 
  • Author and review clinical-regulatory documents, including protocols and amendments, informed consents, study reports, and SAPs   
  • Prepare and deliver scientific presentations and other communication materials for internal and external stakeholders, including investigators and other Maze collaborators. 
  • Engage with scientific thought leaders and patient advocacy groups to gain insights to inform clinical development plans and build awareness and enthusiasm for the Maze pipeline assets. 
  • Partner with Clinical Development Operations to identify and select study investigators and sites and build strong professional relationships with study investigators. 
  • Partner with Clinical Development Operations to identify, select, and oversee vendors and CROs to support program needs. 
  • Develop and integrate timelines and budgets for clinical activities with overall company timelines and goals, in close coordination with project management, CMC, nonclinical development, regulatory affairs, and other stakeholders. 

Skills and Qualifications: 

  • PhD/MD/PharmD with a minimum of 4 years of clinical drug development or a Masters degree with 7 or more years of industry experience. 
  • Prior drug development experience in nephrology or cardiometabolic diseases is preferred but not required. 
  • Experience in the design and conduct of clinical trials and clinical data analysis and in nurturing relationships with investigators, site study staff, patient advocacy groups, and other third parties.   
  • Exceptional organizational, analytical, and communication skills, enabling you to translate corporate objectives into actionable plans that consistently deliver high-quality data on time and within budget. 
  • A positive and enthusiastic disposition, adaptability to changing environments, and unwavering personal and ethical standards in pursuit of corporate goals. 
  • Willingness to travel domestically and internationally (approximately 15%) for vendor visits, industry conferences, regulatory meetings, advisory boards, and other essential gatherings. 

Leadership Competencies

  • Communication and Influence
    • Builds communication channels across Maze for sharing information
    • Influences Senior Management decisions through persuasive arguments
    • Respectfully addresses differing opinions leading to support of decision
  • Teamwork and Collaboration
    • Champions partnerships and connections across Maze
    • Proactively addresses issues that could result in breakdown of team relationships
    • Spotlights team and individual contributions in public forums
  • Execution and Results
    • Addresses gaps and leverages strengths to get best results
    • Maintains a steadying presence and clarifies priorities during change
    • Anticipates and removes barriers that put functional/corporate goals at risk
  • Develop Others and Self
    • Removes barriers to staff development and empowers them to make their own decisions
    • Stays current on industry trends and keeps direct-reports prepared and responsive

About Maze Therapeutics 

Maze Therapeutics is a biopharmaceutical company that is harnessing the power of human genetics to transform the lives of patients, with a focus on genetically informed therapies for common diseases such as chronic kidney disease. Maze applies variant functionalization in tandem with advanced data science methods and a robust suite of research and development capabilities to advance a pipeline of novel precision medicines. Maze has developed the Maze Compass Platform TM, a proprietary, purpose-built platform to understand and integrate the critical step of variant functionalization into each stage of drug development. Utilizing the Maze Compass PlatformTM, Maze is building a broad portfolio of wholly owned and partnered programs. Maze is based in South San Francisco. 

Our People 

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.  

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission. 

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $240,000 to $293,000. Additionally, this position is eligible for an annual performance bonus.  

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.  

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy. 



Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations. 
What are genetic modifiers?
Despite an understanding of the genetic basis for many diseases, it remains a mystery why some people with a disease-causing mutation never get sick. This is often due to genes elsewhere in our DNA that affect the severity of disease and can provide a natural form of protection.
The Maze approach
Dramatic advances in human genetics and functional genomics now enable us to decode the mysteries of genetic modifiers in a range of severe diseases. Today, we believe we can systematically identify genetic modifiers and turn these insights into medicines. We have assembled a world-class team to realize this vision, including creative scientific pioneers, experienced company builders and biotech industry leaders.
Join us in our pursuit to change lives by translating genetic insights into medicine - view our job postings with the link to the left.

Company info
171 Oyster Point Blvd, Suite 200
South San Francisco

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