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Cell Engager New Horizons Portfolio Lead

Boston, Massachusetts
Start date
May 30, 2024

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Job Details

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Job Description

Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a (Title) in our Cambridge office.

At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

Here, you will be a vital contributor to our inspiring, bold mission.

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law


The Oncology Drug Discovery Unit (ODDU) is looking for a Leader who will serve as Senior Director, Cell Engager New Horizons Portfolio Lead reporting into the Tumor Targeted Therapies Drug Discovery Lead. The individual should have strong Drug Discovery experience applying a disease-first strategy focused on understanding and exploiting the underlying mechanisms of a disease to develop creative approaches with lead assets while training a skilled scientific team. This strategic leader is able and willing to contribute to projects moving from target identification and validation through early clinical proof of concept.

This candidate will have a deep comprehension of biology (immuno-oncology biology, biologics, translation), including strong in vivo skills, strong leadership skills, the ability to incorporate emerging approaches into workflows, to provide scientific insights, and the ability to think critically about long-term strategy anticipating the future needs in the field of cell engagers and beyond. The candidate will serve on the scientific leadership team of the ODDU and is responsible for peer review of data package plans, agreement on innovation priorities, generating clear data package expectations that enable the ability to easily track progress and note potential issues. The candidate is expected to be influential across the entire drug discovery spectrum in Research inclusive of partner functions to elevate the Oncology portfolio and in partnership with other therapeutic areas to accelerate development of Takeda’s discovery portfolio.


  • This leader is expected to create, define, and effectively communicate the vision and strategy of the Tumor Targeted Therapies team as it relates to establishing and progressing an industry-leading research portfolio in collaboration with other Portfolio Leads across the DDU.
  • This leader will be responsible for leading research for selected cell engager therapies at Takeda and explore rational combinations in close collaboration with Research and Development project teams, Portfolio Leads, Discovery Leads and Lab Heads across the ODDU to develop the strategies and to enable execution of robust, decision-enabling preclinical and translation experiments.
  • Builds and mentors a team tailored to the vision and strategic imperatives of the ODDU.
  • The leader is a scientific driver for research strategy that partners with CEI (Center for External Innovation) to bring in external innovation to supplement internal pipeline priorities
  • Oversee the work of Discovery Leads and In Vivo focused Lab Head and team providing feedback and detailed scientific guidance and taking corrective action as needed.
  • Develop, drive, and execute the Research plans for selected cell engager programs to support pre-IND packages for the DDU portfolio in partnership with Discovery Leads and Lab Heads and teams.
  • Represent ODDU within R&D and the TAU, as well as to external stakeholders with respect to the cell engager programs being supported.
  • Drive and deliver the pre-clinical development of cell engager programs and across the ODDU portfolio, leveraing resources as needed on key ODDU initiatives and assets.
  • Serve as an experienced thought leader for Immuno-Oncology & Translational Oncology within Takeda, guiding the research strategy and ensuring its successful execution while supporting talent development as a strong mentor and role model for cell engager research.
  • Develop and deliver on the design, execution, and analysis of mechanism of action and proof-of concept studies, in close partnership across ODDU, R&D, and the TAU, including perspective across the continuum of discovery and development with a global perspective.
  • Support business critical decision making for pre-IND packages within the cell engager pipeline, and also the broader Takeda ODDU portfolio.
  • Leverage up-to-date knowledge of drug development and competitive landscape at internal governance bodies as well as at key interfaces with external partners, to guide decision making.
  • Drive biology focus with solid translation and clinical path in partnership with Research and TAU (Therapeutic Area Unit) partners.
  • Provide direction for the identification of new targets aligned with the iDAS (integrated disease area strategy) in collaboration with the Oncology Development Therapeutic Area Unit and the Oncology Business Unit.​
  • Provide significant input into overall ODDU portfolio and department strategy
  • Provide leadership and strategic support across Research, and/or to external collaborators.
  • Responsible for management of resourcing and budget planning for the cell engager field.
  • Ability to work in a highly matrixed environment and establish robust connections between the biology and translational team, engaging cross-functional teams to support projects.
  • Work closely with in-house and external partners in developing solid translational and research plans, in interpreting results, and in determining next steps to maximize patient-centered value of the portfolio.


  • PhD in Immunology or related field with 12+ years of industry experience.
  • 7 (Director)-9 (Senior Director) years of Industry experience required, and 7 (Director)-9 (Senior Director) years of managerial experience required.
  • Excellent knowledge in biologics, immunology, oncology, in vivo experimental design and drug discovery is required.
  • Familiarity with validation of drug targets and the exploratory drug development process. Proven biopharmaceutical industry experience developing and leading innovative therapeutic programs and advancing complex technologies.
  • Excellent oral and written communication skills, including writing, reviewing and editing scientific documents and presenting to a range of stake-holders.
  • Ability to work and drive decision-making within a multi-disciplinary, multi-regional, matrix teams with a global perspective with cultural competency.
  • Good fit with Takeda core values and leadership principles, including the highest personal values and ethical standards.
  • Takeda’s high-engagement and ONE Research DEI culture is an important factor in our success; we seek team members who will contribute to and further strengthen that culture in all ways of working
  • Right attitude (agile, curious, positive, open-minded, “can-do” mindset), must be willing and able to be “hands on,” results-oriented mindset.
  • Effective leadership, people management, communication skills, and a team builder management style are essential.
  • Ability to take an enterprise mindset to enable the success of Takeda.


Takeda Compensation and Benefits Summary

We understand compensation is an important factor as you consider the next step in your career. We are committed to equitable pay for all employees, and we strive to be more transparent with our pay practices.

For Location:

Boston, MA

U.S. Base Salary Range:

$205,100.00 - $322,300.00

The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for short-term and/or long-termincentives. U.S.based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others. U.S.based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


Boston, MA

Worker Type


Worker Sub-Type


Time Type

Full time


Takeda is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to discover and deliver life-transforming treatments, guided by our commitment to patients, our people and the planet. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people’s lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions.

For more information, visit

Stock Symbol: TAK

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650 East Kendall Street

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