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Senior Scientist, Protein Engineering

Employer
Life Edit Therapeutics
Location
Durham, NC
Start date
May 23, 2024

View more

Discipline
Science/R&D, Biotechnology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Bio NC

Job Details

The Role: 

Technology Development at Life Edit Therapeutics discovers and establishes CRISPR genome editing capabilities through protein and RNA engineering and optimization. We also deliver early therapeutic leads that supports internal and external programs for curative gene and cell therapies.  We are looking for an experienced scientist with a strong background in directed evolution of CRISPR editors for our ongoing protein engineering projects aiming to deliver effective genome editors for downstream therapeutic programs. This is an exciting opportunity to contribute to making of genetic medicines that impact patient’s life and helping build a successful therapeutics company from an early stage.

 

Here’s What You’ll Do:

  • Develop a continuous evolution platform to evolve CRISPR editors.
  • Validate this high throughput platform for engineering CRISPR editors on therapeutically relevant targets by demonstrating improvement in activity and specificity of genome editing both in vitro and in vivo.
  • Participate in other research projects according to company needs.
  • Work with multidisciplinary teams and program managers to ensure achieving milestones on time.
  • Analyze experimental results and communicate data at internal and external research meetings.
  • Contribute to publications and patent applications.
  • Follow advancements in the field of gene editing and gene therapy published in the literature and presented at conferences.

 

Requirements:

  • Ph.D. in Biochemistry, Molecular Biology, Cell Biology, or a related field with 2+ years of experience.
  • Hands on experience in molecular biology, directed evolution and protein engineering.
  • Experience in developing and using continuous evolution to evolve CRISPR editors or related systems.
  • Demonstrated ability to work independently and collaborate in a team-oriented environment.
  • Strong oral and written communication skills

Why join Life Edit and the ElevateBio ecosystem?

Life Edit Therapeutics is an integrated subsidiary of ElevateBio, a technology-driven cell and gene therapy company that is accelerating access to the cutting-edge technologies and expertise that can change the future of medicine. Our integrated model combines multiple R&D technology platforms – including Life Edit gene editing – and cGMP manufacturing to power the discovery and development of advanced therapeutics. Our ecosystem is designed to enhance speed, delivery, and probability of success to change patient lives.

Life Edit is an integral part of ElevateBio’s ecosystem of platform technologies and is pioneering focused next-generation gene editing technologies and therapeutics. Located in Durham, NC, members of Life Edit work closely with the ElevateBio Research and Development and BaseCamp manufacturing teams in Waltham, MA. Life Edit is advancing therapeutic programs in collaboration with industry partners while building its own internal pipeline of gene editing therapies. We are looking for a unique individual who can continue to lead the cultural development of Life Edit and build on its momentum as an integral part of the ElevateBio ecosystem.

Our Mission:
To power the creation of life-transforming cell and gene therapies, at a speed the world deserves.

Our Vision:
We seek to be the world’s most indispensable cell and gene therapy technology company, redefining how companies operate, how products are created and how disease is treated.

ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Company

Life Edit Therapeutics is an ElevateBio company focused on advancing next-generation gene editing technologies and therapeutics. Life Edit has built a highly innovative platform with one of the world’s largest and most diverse libraries of RNA-guided nucleases (RGNs), base editors, and reverse transcriptase (RT) editors that provide flexible editing and unprecedented access to the genome. The platform allows Life Edit to target any genomic sequence and potentially develop novel human therapeutics for the most challenging genetic diseases by enabling ex vivo engineering for cell therapies and regenerative medicines and in vivo delivery of gene therapies.

Company info
Website
Location
300 Morris Street, Suite 300
Durham
NC
27701
US

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