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Principal Data Scientist Bioinformatics Technologies

South San Francisco, California
Start date
May 21, 2024

Job Details


If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. Its time for a career you can be proud of.

Principal Data Scientist - Bioinformatics Technologies


What you will do

Lets do this. Lets change the world. In this vital role you will join the Bioinformatics Technologies team within Amgens Center for Research Acceleration by Digital Innovation (CRADI). CRADI is a multi-disciplinary effort embedded within our drug discovery engine that continually uses advancement in digital technologies for disease modeling and digital modality engineering to accelerate our pipeline from target inception through drug development. This pivotal role within CRADIs Computational Biology and Bioinformatics platform will assist in establishing an innovation engine for deploying and exploiting emerging digital technologies in the field of computational biology.

In this role you will set strategy, develop, and implement computational models on multi-modal, multi-omics data to accelerate the execution of strategic imperatives for preclinical biomarker discovery. Work collaboratively with scientists within preclinical research and clinical biomarkers as well as data scientists and engineering partners across Amgen R&D. An ability to communicate clearly and collaborate effectively with colleagues from different fields will be essential.

  • Design, execute, interpret, and report on multi-dimensional studies using bulk, single-cell, and spatial omics technologies that will expedite the pace of research biomarker discovery and translation in early drug discovery across therapeutic areas

  • Find opportunities and set strategy for digital innovation in the field of computational biology

  • Initiate and lead the development of advanced quantitative methods, such as topological data analysis, causal inference, discriminative, and generative AI/ML, to push the state of the art in integrative omics-based biomarker detection

  • Collaborate with engineers, data scientists, and research scientists to develop innovative bioinformatics tools and cloud-native workflows that facilitate data access, model utilization, and output interpretation

  • Serve as subject matter expert for multi-modal single-cell and spatial omics technologies

  • Mentor junior data scientists and engineers, providing technical guidance within a formal or matrix structure

  • Advise stakeholders on omics data generation, analysis, and interpretation

  • Translate findings into computational model design and refinement

  • Document methods and analyses to ensure reproducible research

  • Communicate project results and data-driven recommendations to collaborators and cross-functional partners

  • Monitor, review, and critically interpret published computational research in the field of computational biology and bioinformatics


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a scientist with these qualifications.

Basic Qualifications:Doctorate degreeOr

Masters degree and 6 years of computational biology, bioinformatics, biomedical data science or related field


Bachelors degree and 8 years of computational biology, bioinformatics, biomedical data science or related field

Preferred Qualifications:
  • PhD in computer science, data science, computational biology or bioinformatics

  • Extensive experience and a deep theoretical understanding of statistical modeling, machine learning, deep learning, causal learning, topological data analysis, and other relevant quantitative methods

  • Proven record of innovative thinking to propose and champion the development of novel algorithms and AI/ML models that generated interpretable and actionable results for biomarker discovery

  • Solid knowledge in molecular biology and genetics

  • Comprehensive understanding of drug discovery and development process

  • Skilled in integrative analysis of omics data, including single-cell and spatial sequencing data

  • Proficient in systems biology, such as in silico modeling of cellular response to drug or genetic perturbations

  • Fluency in scientific programming and tool development with R, Python, or equivalents

  • Familiarity with Dev/MLOps and software best practices, such as version control, continuous integration, test driven development

  • Experienced in cloud computing

  • Creative and open-minded, with a passion for scientific research

  • Exceptional analytical skills, capable of collecting, organizing, analyzing, and disseminating significant amounts of information with attention to detail and accuracy

  • Demonstrated ability to thrive in a team environment

  • Strong interpersonal, collaborative, organizational, and presentation skills

  • Excellent communication skills, both written and verbal


What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.

  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

  • Stock-based long-term incentives

  • Award-winning time-off plans and bi-annual company-wide shutdowns

  • Flexible work models, including remote work arrangements, where possible

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.


We are all different, yet we have this in common: our mission to serve patients. This sense of shared purpose is key to our becoming one of the world’s leading biotechnology companies. It guides us as we continue to launch new medicines and reach millions of patients worldwide.

We live the mission.

We win together.

We thrive on continual challenge.

Our team of 22,000+ scientists and professionals worldwide bring distinct perspectives and experiences to all we do. We leverage our global talent to achieve together—to research, manufacture and deliver ever-better products and greater depth to our mission.

At Amgen, there is a strong correlation between our high level of diversity and performance. Because addressing issues with a wider range of perspectives and approaches leads to more creative problem-solving. Together, we’re transforming the promise of science and biotechnology into therapies that have the power to restore health.

Connect with us to explore how you can Win, Live, and Thrive at Amgen.

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Company info
Corporate Headquarters
One Amgen Center Drive
Thousand Oaks

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