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Senior Director, IT

Maze Therapeutics
South San Francisco, CA
Start date
May 9, 2024

Job Details

The Position:

Are you ready to shape the future of technology in the dynamic world of biotechnology?  As the Senior Director of IT at Maze, you’ll spearhead strategies that power our technology applications, platforms, and infrastructure.  In this role, you’ll be at the forefront of ensuring availability, integrity, security, and compliance of all IT systems and infrastructure.  Your mission is to not only meet our current technological needs but also seamlessly align them with our long-term business objectives, collaborating closely with departments such as Finance, HR, Legal, Quality, Clinical, Pharmacovigilance, Regulatory, Research Infrastructure and Technical Operations.  Join us in creating a tech landscape that propels our company to new heights.

Your Impact:

  • Provide leadership, vision, and direction to establish and implement a right-sized IT strategy and systems to align with Maze's stage of development and projected growth.
  • Spearhead the transition to a cloud-first computing infrastructure collaborating closely with Informatics and Data Science teams to ensure a seamless integration.
  • Prioritize and oversee a diverse portfolio of IT projects, each strategically aligned with Maze’s business goals.
  • Elevate company efficiency and productivity by refining and maintaining key scientific and business systems.
  • Uphold the highest standards of IT security and compliance, ensuring adherence to regulatory requirements such as SOX, GDPR, and more.
  • Develop enterprise standards, technology architecture, and IT operations governance processes to help guide efficient IT investment across the organization.
  • Continually evaluate IT out-sourcing opportunities versus building core competencies and engage consultants/where appropriate.
  • Help define and execute long-range strategic IT projects by leading cross-functional project teams.
  • Ensure key strategic IT initiatives are delivered on time and within budget, maintaining the highest quality standards throughout.
  • Foster strong relationships across the organization and with external partners and vendors, ensuring alignment and effective collaboration.
  • Mentor and build a team of IT professionals, empowering them to deliver our IT strategy and drive business success.
  • Lead effectively in a diverse, team-oriented environment and develop solid, working relationships at all levels across the organization and with external partners and vendors.

As a Senior Director, we also expect our leaders to demonstrate the following Leadership Competencies:

Leadership Competencies

  • Communication and Influence
    • Role models clear communication and open two-way conversations.
    • Reinforces an environment where people feel heard and their opinions are valued.
    • Inspires followership despite differing initial opinions.
  • Teamwork and Collaboration
    • Champions collaboration and connection across Maze.
    • Establishes team norms and expectations.
    • Seeks opportunities to spotlight team and individual contributions in public forums.
  • Execution and Results
    • Develops recommendations to seize on opportunities and mitigate obstacles that could impact long-term success.
    • Coaches others on resource management and work distribution/delegation.
    • Aligns work to Maze’s strategy mission and vision.
  • Develop Others and Self
    • Develops staff capabilities to handle delegation of responsibilities.
    • Encourages staff to develop and execute personal stretch goals.
    • Identifies and recommends ways to increase inclusive leadership.

Skills and Qualifications:

  • Bachelor’s degree in computer science/business administration or an equivalent level of education and comparable experience with 10+ years of industry experience in Biotech, Pharma or Life Sciences Company including 5+ years of IT Leadership.
  • Experience working within a clinical stage, public company biotech environment
  • Proven experience managing IT services and solutions in a SaaS cloud environment, with a knack for developing strategic system roadmaps.
  • Exceptional vendor management skills and the ability to forge strong relationships with key stakeholders and client executives.
  • Thrive in a fast-paced IT environment, capable of distilling technical concepts for non-technical audiences and managing multiple projects simultaneously.
  • Extensive experience in regulated environments, with a deep understanding of structured and agile SDLC methodologies, computer systems validation processes, and regulatory frameworks such as FDA, GAMP 5, and GDPR.
  • Strong leadership, communication, and interpersonal skills, with a track record of building and leading high-performing teams.

Join us at Maze a be a part of a team that’s revolutionizing the intersection of technology and biotechnology. 

About Maze Therapeutics

Maze Therapeutics is a biopharmaceutical company that is harnessing the power of human genetics to transform the lives of patients, with a focus on genetically informed therapies for common diseases, such as chronic kidney disease, and seeks to focus expertise and resources towards underserved communities. Maze applies variant functionalization in tandem with advanced data science methods and a robust suite of research and development capabilities to advance a pipeline of novel precision medicines. Maze has developed the Maze Compass Platform™, a proprietary, purpose-built platform to understand and integrate the critical step of variant functionalization into each stage of drug development. Utilizing the Maze Compass Platform™, Maze is building a broad portfolio of wholly owned and partnered programs. Its two lead programs are focused in Chronic Kidney Disease (CKD), a condition that impacts an estimated 37m individuals. The first program in CKD addresses a genetic subset of the common disease that has a disproportionate impact on the Black Community. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. 

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission. 

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $254,000 -$311,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.


Maze Therapeutics is translating novel genetic insights into lifesaving medicines, through an approach that integrates human genetics and functional genomics. Advances in these areas have enabled us to decode the mysteries of genetic modifiers in a range of severe diseases, which we aim to turn into medicines that mimic protective mutations. 
What are genetic modifiers?
Despite an understanding of the genetic basis for many diseases, it remains a mystery why some people with a disease-causing mutation never get sick. This is often due to genes elsewhere in our DNA that affect the severity of disease and can provide a natural form of protection.
The Maze approach
Dramatic advances in human genetics and functional genomics now enable us to decode the mysteries of genetic modifiers in a range of severe diseases. Today, we believe we can systematically identify genetic modifiers and turn these insights into medicines. We have assembled a world-class team to realize this vision, including creative scientific pioneers, experienced company builders and biotech industry leaders.
Join us in our pursuit to change lives by translating genetic insights into medicine - view our job postings with the link to the left.

Company info
171 Oyster Point Blvd, Suite 200
South San Francisco

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