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Senior Scientist II - Protein Mass Spectrometry

Irvine, CA
Start date
May 9, 2024

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Science/R&D, Biotechnology
Required Education
Masters Degree/MBA
Position Type
Full time
Biotech Beach, Best Places to Work

Job Details

Company Description

At Allergan Aesthetics, an AbbVie company, we develop, manufacture, and market a portfolio of leading aesthetics brands and products. Our aesthetics portfolio includes facial injectables, body contouring, plastics, skin care, and more. Our goal is to consistently provide our customers with innovation, education, exceptional service, and a commitment to excellence, all with a personal touch. For more information, visit Follow Allergan Aesthetics on LinkedIn.

Job Description

The Toxins Innovation team in discovery research is seeking a self-motivated, discovery-oriented, senior research scientist with a proven industry track record in leading mass spectrometry-based protein characterization projects and initiatives. This is a senior, laboratory-based role, and the successful candidate is expected to have significant industry experience with an emphasis on driving discovery projects through important stage gates to meet business goals. The Senior Scientist I/II is responsible for identifying, developing, and implementing analytical methods for the characterization of proteins and peptides with an emphasis on mass spectrometry, including intact mass and peptide mapping. The ability to contextualize and communicate scientific findings and impact in terms of biological mechanism and project relevance is critical. Expertise in data collection and data analysis software for these assays is a requirement. Mass Spec-based proteomics and pull-down assay experience are desirable. Additional experience with analytical and separation techniques such as capillary electrophoresis (CE-SDS, cIEF) is beneficial.

He/She/They will be expected to independently identify, design, and execute research plans in support of Toxins Innovation discovery projects including collecting and interpreting detailed MS data, generating formal reports, and orally presenting findings within team-basedsettings. The Senior Scientist I/II will also be responsible for generating reports for management to support the advancement of discovery molecules through the research pipeline. He/She/They will serve as a functional SME for the analytics team to provide feedback and guidance to diverse cross-functional project teams. He/She/They will maintain a productive and collaborative laboratory environment consistent with group and company expectations.

The position requires the individual to work with and in areas requiring select agents and toxins access (i.e. Biosafety level 2 laboratories). Access to and use of select agents is regulated by federal policies. Therefore, the candidate must conduct all work activities in compliance with AbbVie internal and applicable regulatory requirements. AbbVie internal requirements include compliance with ethics, environmental health and safety, financial, human resources, and general business policies, requirements, and objectives.


  • Identify, design, and execute research plans in alignment with Toxin Innovation discovery pipeline goals. Drive cutting-edge, scientific initiatives to progress early-stage discovery molecules through major pipeline stage gates.
  • Effectively contextualize and communicate complex scientific data to a wide audience of scientists and SMEs.
  • Identify, develop, and implement novel analytical methods for the characterization of biopharmaceuticals with an emphasis on LC-MS and biophysical characterization to drive discovery projects through the research pipeline.
  • Represent the analytical team as a functional lead on cross-functional teams and provide support to other groups and external departments. Openly share scientific expertise and collaboratively help the team to formulate rational solutions to problems.
  • Maintain a thorough and current knowledge of the scientific and technical literature pertinent to the project and necessary for development of state-of-the-art analytical methods, including the acquisition and implementation of necessary equipment.



  • Masters or Doctorate degree in biochemistry, biophysics, molecular biology, or related field
  • 10+ years of industry experience (Masters) or 4+ years of industry experience (Ph.D.), preferably in a discovery research setting.
  • Experience leading industry projects in support of discovery pipeline goals with minimal oversight from management.
  • Extensive industry experience with the application of mass spectrometric, separation, and biophysical techniques for the characterization of proteins and their degradation and modification products.
  • Expert-level experience with SYNAPT systems for intact MS and Orbitrap-based systems for bottom up peptide mapping techniques is a requirement.
  • Mature knowledge of the biopharmaceutical development process and strong ability to communicate findings with scientists at various stages of the development pipeline.
  • Highly proficient in using data analysis software such as BioPharma Finder or Protein Metrics.
  • A strong understanding of additional methods and procedures related to the production and characterization of biopharmaceuticals is expected.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at the time of this posting based on the job grade for this position. Individualcompensation paid within this range will depend on many factors including geographic location, and we may ultimatelypay more or less than the posted range. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/visioninsurance and 401(k) to eligible employees.

This job is eligible to participate in our short-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable.The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefitsthat are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent with applicable law

Additional Information

AbbVie is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVies policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.


AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.

Stock Symbol: ABBV

Stock Exchange: NYSE

Company info
1 North Waukegan Road
North Chicago

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