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Director, Mass Spectrometry & Immunopeptidomics

Moderna, Inc.
Cambridge, MA
Start date
May 1, 2024

Job Details

The Role:

We are seeking a talented, motivated and proven scientific leader to expand our capabilities and capacity for mass spectrometry (MS) and immunopeptidomic work flows across discovery and pre-clinical Cancer Vaccine Research (CVR) initiatives. The successful candidate will be a technical expert and recognized leader in the MS/immunopeptidomics field ideally with experience in the discovery and pre-clinical development of novel medicines for cancer patients, and at minimum, an interest in being an essential partner to our CVR discovery, preclinical development and platform objectives. A strong background in immunology, proteomics, and cancer vaccines in addition to the successful leadership of a research team in regard to scientific, technical, strategic and people management are essential to help us maximize the impact we will have on cancer patients.

Here's What Youll Do:

  • Lead, manage and expand the MS and immunopeptidomic analysis workflows in the context of cancer vaccine research, including sample preparation, LC-MS/MS analysis, and data interpretation; for target discovery and validation, as well as related efforts to further characterize and optimize our cancer vaccine platform.

  • Build internal and leverage external resources to ensure utilization and leverage of cutting edge technologies and processes.

  • Develop and implement new methods and technologies to enhance immunopeptidomic analysis capabilities for the discovery and validation of tumor-associated antigens and neoantigens.

  • Collaborate with the Computational Sciences team to analyze and interpret immunopeptidomic data, and integrate it with genomic and transcriptomic data to guide the design of cancer vaccines.

  • Provide scientific leadership and guidance to team members, fostering an environment of innovation and excellence.

  • Collaborate with other research teams to integrate immunopeptidomic data with other research areas, such as immune monitoring and vaccine efficacy studies.

  • Contribute to the writing and reviewing of scientific manuscripts, grants, and patents related to cancer vaccine research.

  • Present findings at internal meetings and international conferences.

  • Ensure compliance with all applicable regulations and maintain up-to-date knowledge of literature in the field of cancer vaccines and immunopeptidomics.

  • Serve as further nucleus and leader in our across company MS Working team (including individuals in Protein Sciences, Infectious Disease Research, Technical Development and Immune Therapeutics Discovery).

Heres What Youll Bring to the Table:

  • PhD in Immunology, Biochemistry, Molecular Biology, or a related field.

  • A minimum of 9 years of postdoctoral experience in immunopeptidomic analyses related to cancer vaccine discovery, validation and early development.

  • Extensive experience with LC-MS/MS and related proteomic technologies, including in depth knowledge of state-of-the-art equipment from Bruker and Thermo Fisher.

  • Proficiency in bioinformatics tools and software used in immunopeptidomic analysis.

  • Strong track record of team and project leadership, and scientific publications in the field of cancer vaccines and/or immunopeptidomics.

  • Excellent leadership, communication, collaboration and project management skills.

  • Ability to work in a fast-paced, dynamic, team-oriented environment working on multiple projects with aggressive timelines.

Preferred Qualifications:

  • Experience with antigen presentation and T cell biology and related assays beyond MS/immunopeptidomics in the context of cancer immunotherapy.

  • Experience with other omics technologies, such as genomics and transcriptomics, in relation to cancer vaccine research.

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

  • Highly competitive and inclusive medical, dental and vision coverage options
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
  • Family care benefits, including subsidized back-up care options and on-demand tutoring
  • Free premium access to fitness, nutrition, and mindfulness classes
  • Exclusive preferred pricing on Peloton fitness equipment
  • Adoption and family-planning benefits
  • Dedicated care coordination support for our LGBTQ+ community
  • Generous paid time off, including:
    Vacation, sick time and holidays
    Volunteer time to participate within your community
    Discretionary year-end shutdown
    Paid sabbatical after 5 years; every 3 years thereafter
  • Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
  • 401k match and Financial Planning tools
  • Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
  • Complimentary concierge service including home services research, travel booking, and entertainment requests
  • Free parking or subsidized commuter passes
  • Location-specific perks and extras!

About Moderna

Since our founding in 2010, we have aspired to build the leading mRNA technology platform, theinfrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.

By living our mission, values, and mindsets every day, our peopleare the driving force behind our scientific progress and our culture.Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.

As we build our company, we have always believed an in-person culture is critical to our success. Moderna champions the significant benefits of in-office collaboration by embracing a 70/30 work model. This 70% in-office structure helps to foster a culture rich in innovation, teamwork, and direct mentorship. Join us in shaping a world where every interaction is an opportunity to learn, contribute and make a meaningful impact.

If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit to learn more about our current opportunities.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!

Moderna is proud to be an equal opportunity workplace and is an affirmative action employer.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.

Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. Were focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.

Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should contact the Accommodations team at (EEO/AAP Employer)




Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. Moderna’s platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, providing the Company the capability to pursue in parallel a robust pipeline of new development candidates. Moderna is developing therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases and cardiovascular diseases, independently and with strategic collaborators.

mRNA is now a turning point in the history of science, medicine, technology, even humankind itself. With this breakthrough discovery, many of the world’s biggest and most challenging medical problems are no longer a question of “how?” but merely a question of “when?”

Come with us as we pursue the uncharted reaches of possibility and make your mark on the future of medicine.


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Company info
200 Technology Square
Cambridge, MA

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