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Senior Scientist – Discovery Biology

Employer
Nurix Therapeutics
Location
San Francisco, CA
Start date
May 8, 2023

View more

Discipline
Science/R&D, Biology, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay

Job Details

We are seeking a highly skilled and motivated immunologist to support Nurix’s mission of targeting E3 ubiquitin ligases in the areas of oncology and immunology. This individual will work closely with our drug discovery project scientists on lead optimization of novel compounds to evaluate the impact on immune cells and characterize their MOA. The candidate must be self-driven, organized, able to work well with other scientists, and able to thrive in an exciting environment in a rapidly-growing company.


Qualifications

  • PhD. in immunology, inflammation, cancer biology or related field (or Bachelor’s/Master’s degree with >8-10 years industry experience)
  • Research experience in the field of immunology with a focus on immune cells and tumor biology
  • Expertise in functional assays measuring cellular activation, cytokine release, proliferation, and killing
  • Hands on experience in development, optimization and execution of high-dimensional flow cytometry to phenotypically characterize immune cells including both surface and intracellular staining, primary human and mouse cell isolation, ELISA, Western and multiplexing technologies
  • Experience with genetic validation in primary cells or model systems utilizing molecular techniques including shRNA/CRISPR knockdown to support target validation and mechanism of action studies for drug candidates
  • Background in ubiquitin biology with past experience is a plus
  • Develop novel ideas/technologies, eager to learn, innovate.
  • Propose and implement resolutions to technical problems/issues.
  • Work with departmental and/or cross functional peers to execute on assignments

Fit with Nurix Culture and Values

Strong team orientation; highly collaborative; solutions and results-oriented focus

Strong scientific curiosity and initiative; hands-on and resourceful

Self-driven and enthusiastic with the ability to thrive in a dynamic environment


Company

Nurix, Inc. is a science-minded, goal-oriented organization that is focused on bringing novel, first-in-class therapies to patients. Nurix is a leader in discovering a new class of drugs that work by modulating the protein degradation machinery of the cell. The Nurix scientific team has established an innovative drug discovery platform based on recent advances in understanding of the ubiquitin proteasome system (UPS). The UPS is a regulatory network that controls protein stabilization and degradation, a function vital to the healthy life of a cell, uncovering therapeutic opportunities in multiple disease areas.

Nurix’s Protein Regulation Platform enables the discovery of selective inhibitors or activators of the UPS, enabling the discovery of new class of drugs that can restore normal cellular homeostasis. Nurix entered into an exclusive collaboration with Sanofi and Gilead for the discovery and development of next-generation therapies targeting protein homeostasis in oncology, immunology and inflammation, including the rapidly evolving field of immuno-oncology. 

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Company info
Website
Phone
415-660-5320
Location
1700 Owens Street
Suite 205
San Francisco
California
94158
US

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